DNA methylation got your expression down? Why not try targeted demethylation with Casilio-ME? CRISPR/Cas9 techniques have been applied to numerous biological tasks including regulation of DNA methylation. 5-methyl cytosine (5mC) is deposited by DNA methyltransferases (DNMTs) and removed by step-wise oxidation via the three ten-eleven translocation (TET) enzymes; 5mC is first converted to 5-hydroxymethylcytosine (5hmC), […]
- "epigenetic editing"
Search Results for: epigenetic editing
Maladaptive Memories are Mediated by Methylated Histones and ΔFosB in the Mouse Hippocampus
The air is starting to get crisp, the first few leaves are changing color and you can suddenly buy pumpkin-spice everything – these contextual cues can only mean one thing; you’d better start studying for your midterms! But wait, you haven’t had to worry about exams for years… Thanks to your hippocampus and epigenetics, environmental […]
Methylation Prevents Young Transposable Elements From LINE-1 Dancing Through the Neural Genome
Whether you’re a fan of nightclubs, speakeasys, or honkey-tonks, you may have noticed that the population on the dance floor seems to get younger every year. Maybe you’re just getting older, or maybe today’s youth are getting better at getting around the rules. Like bouncers at a bar, developing cells have DNA methylation to keep […]
Mitochondrial Memes: How the Powerhouse of the Cell also Drives Epigenomic Alterations
The appreciation of the mitochondrion as “the powerhouse of the cell” has become as culturally pervasive as some of our favorite memes; however, a powerful new study now shows that signals deriving from this double-membrane-bound ATP-generating organelle represent a major driving force behind alterations to the epigenome. A talented team of researchers from the lab […]
YY1 Drives Enhancers and Promoters Loopy!
Cell culture hood in disarray? Favorite coffee cup missing? Internet running slow? What exactly drives you loopy in the laboratory?! Recently, the lab of Richard A. Young (Whitehead Institute for Biomedical Research, Cambridge, USA) has been driven round the bend in their quest to understand what controls the DNA looping process that brings together enhancers […]