While it’s never a great idea to stare directly into the sun, a DNA methyltransferase (DNMT) eclipse brought to you by the SunTag system may just steal your eyes during its totality. This designer epigenome editing system comes to you from the labs of Margaret A. Goodell and Wei Li at Baylor College of Medicine […]
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Search Results for: epigenetic editing
LINE-1 Retrotransposons Keep Early Embryonic Chromatin in Line
While cocktails and embryonic development usually don’t mix well, a cocktail of three transcription-activator-like effectors (TALEs) has just shaken up our understanding of the role LINE-1 retrotransposons during early embryonic development. LINE-1 activation had been considered a consequence of developmental processes, but now a talented team from the lab of Maria-Elena Torres-Padilla at the German […]
Running in Circles: circRNAs Act as Shuttles for miRNA Cargo
Feeling out of the loop about all the different non-coding RNAs being described? Well hold on, because circular RNAs (circRNA) are about to throw you for a loop. Mammalian circRNAs are created by covalent closure of transcribed exons into loops. These circRNAs are highly expressed in specific brain regions, and conserved between mice and humans. They […]
Epromoters: Two Great Regulatory Functions for the Price of One!
Not many people can resist the allure of the ubiquitous neon signs promising fantastic two-for-the-price-of-one offers that promise to double the value of their hard-earned cash. Interestingly, these bargain offers also seem to be a feature in the human genome as a subset of promoters provide extra value by also acting as enhancers for other […]
HDACking Histone Acetylation With dCas9-HDAC3
Hacking the epigenome is no easy task. Each deactivated Cas9 (dCas9) system boasts its own nuances that must be teased apart before we can crack the histone code with its suite of effector domains. When it comes to histone acetylation, we’ve seen the histone acetyltransferase construct dCas9-p300, which writes H3K27ac to activate gene expression. However, […]