Some of our most touted advancements in weaponry involve ‘surgical strike capabilities’, the idea being that the more precisely you attack a specific target, the less unintended damage there will be. Recent innovations in genome editing, such as CRISPRs and TALENs, may provide researchers with an improved genomic targeting system, enabling more precise aiming towards […]
- "epigenetic editing"
Search Results for: epigenetic editing
Cutting Edge HIV Therapy with Zinc-Finger Nucleases
Although HIV can nowadays be successfully managed with a cocktail of antiretroviral drugs that inhibit replication, the virus remains latent in the genome of infected individuals waiting to come out full throttle whenever it is given the chance. Therefore the hunt is still on for a strategy to give HIV infected cells the final blow. […]
Chromatin Packaging in Embryonic Stem Cells and Sperm
Fitting all that chromatin into a tiny package is no easy ordeal, especially when pristine nuclear architecture is so crucial to things like cancer prevention. In order to learn more about the chromatin packaging of mouse embryonic stem cells (ESCs) and sperm, a team from the University of Massachusetts Medical School laid out some high-resolution nucleosome and transcription factor […]
CATCH-IT
Looking to CATCH a glimpse of chromatin dynamics? Well CATCH-IT if you can. Covalent attachment of tags to capture histones and identify turnover (CATCH-IT) is used to estimate the rates of assembly, disassembly or turnover of native nucleosomes. First, cells are treated with the methionine analog azidohomoalanine (AHA). AHA is incorporated into newly-synthesized proteins including […]
CRISPR/Cas9 Caught Causing A Cure
The CRISPR/Cas9 genetic editing system has soaked up the media spotlight faster than anything not named Kardashian. But unlike that famous clan, recent research indicates that there may be good reason that the science paparazzi just can’t seem to get enough of CRISPR/Cas9. After making the leap from basic discovery to zebrafish to monkeys, a […]