Long non-coding RNA research isn’t just a load of HOTAIR; since their initial discovery long non-coding RNAs have revealed their importance in regulating the genome. One such insight is the observation that lncRNA express antisense transcripts, which are abundantly found either partially or completely overlapping with transcripts from the opposite strand. These have been shown […]
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Search Results for: epigenetic editing
CRISPR Gets Creative with Histone Acetylation
There’s been a lot of firsts in the world of genome editing happening lately, from its application in human embryonic stem cells, the identification of a smaller more versatile Cas9, to its upgrade to efficiently using homology-directed repair. Now CRISPR-Cas9 is getting its feet wet with epigenome editing thanks to the clever folks in the Gersbach lab […]
DNMT1 Loss is Lethal in Human But Not Mouse Embryonic Stem Cells
Mouse models have been great to science, they’ve given insight into humans in ways simply not possible in humans. However, while there are striking similarities in the epigenetics of mice and men, there are also undoubtedly some fundamental differences. Now, a team from the Broad Institute of MIT and Harvard consisting of the labs of Alexander Meissner, J. Keith Joung, and John […]
5hmC: a Helping Hand in Drug Addiction
While there’s no doubting that one month of continuous cocaine exposure is going to have an effect on the brain, it seems that some of the molecular culprits behind the response and long-term effects are 5hmC and the TET protein family. An international research team studying addiction via cocaine show that repeat exposure downregulates the TET machinery in the brain’s reward centre, the nucleus […]
Express Yourself with Light-activatable CRISPR-Cas9
Guess what? It seems that blue light has a lot more to offer than just helping with your winter time blues. It could also be just what your transcriptional activation system needs. Synthetic biology has a lot to offer omics beyond genome editing and recent work from multiple groups is putting Cas9 in a different spotlight. CRISPR/Cas9 […]