The way in which DNA methylation on a genomic scale, aka the Methylome, gets established, maintained and sometimes altered has profound implications for biological research and understanding, and may someday lead to advanced therapies for a variety of diseases. Olivia May’s article delivers more details about the inner working of the Methylome, and what it […]
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Search Results for: epigenetic editing
Zinc Fingers Clinch Clinical Gold Medal Against HIV
It’s a little late to qualify for the 2014 Winter Olympics, but Genome Editing still scored a huge translational gold medal. Deploying Zinc Finger Nuclease (ZFN) genome editing techniques, researchers have edited the CCR5 ‘trojan horse’ receptor that HIV uses to infect our immune system’s vital CD4 T cells. ZFNs have shown promise with their combination of […]
Natural Antisense Transcripts within Pseudogenes
EpiGenie recently reviewed the epigenetic text Non-Coding RNAs and Epigenetic Regulation of Gene Expression by Kevin Morris. To give you a little taste of the material covered in the book, here is a summary of one of the chapters: Natural Antisense Transcripts within Pseudogenes: An EST Survey by Enrique M. Muro and Miguel A. Andrade-Navarro […]
Small RNA-mediated Gene Activation
EpiGenie recently reviewed the epigenetic text RNA and the Regulation of Gene Expression by Kevin Morris. To give you a small taste of the material covered in the book, here is a summary of one of the chapters: Small RNA-mediated Gene Activation by Long-Cheng Li Noncoding RNAs (ncRNA) which, by definition, do not code for […]
tiRNAs Emerge from FANTOM4
As deep sequencing platforms displace Nintendo’s Wii as the most popular toy in the research community, labs are discovering new varieties of RNAs at a dizzying pace. The latest edition, transcription initiation RNAs (tiRNAs), were recently identified by scientists at the University of Queensland in Australia, and published in Nature Genetics last April, by mining […]