Novel Multiomic Epigenetic Clock May Decipher How Epigenetic Aging Impacts Cell FunctionAugust 23, 2022Timely advances have demonstrated that significant changes to DNA methylation levels accompany the creaking knees, failing eyes, and changing tastes in music (!) associated with the human aging process. A well-timed study now builds upon these past studies to describe a multiomic-based approach with the potential to forge links between epigenetic aging and the gene […]
APOE Tips Heterochromatin Balance Towards Stem Cell Senescence and AgingApril 11, 2022Like a healthy balance between work and play can enhance our day-to-day lives, a new study suggests that stem cells require a healthy epigenetic balance between silent and active chromatin domains to support their ongoing normal functions. More specifically, researchers headed by the well-balanced quartet of Moshi Song, Weiqi Zhang, Jing Qu, and Guang-Hui Liu […]
Has Cannabis Gone Up in Smoke? – Study Links Use to Accelerated Epigenetic AgingMarch 31, 2022Like there is no smoke without fire, another study has linked cannabis use to unwanted epigenetic alterations. We’ve seen that cannabis exposure alters DNA methylation in prenatal mouse brains (influencing subsequent behavior), the sperm of rats and humans (priming an autism spectrum disorder-like profile), and human adult brains (impacting brain function), and now epigenetic aging […]
“Is this the real-life? Is this just fantasy?” – CultureAGE Shows How In Vitro Studies Reflect In Vivo Epigenetic AgingFebruary 21, 2022Profiling epigenetic aging with in vitro cell models may allow for a deeper understanding of the difficult-to-decipher in vivo process, but only if one truly reflects the other; this leaves us wondering: “Is this the real-life? Is this just fantasy?” In their epigenetic rock opera, bohemians from the lab of Morgan Levine (Yale School of […]
Down the Wrong Path: Trisomy 21 Pushes Neural Progenitors Towards Senescence ProfileJanuary 31, 2022Although it sometimes feels like there is no right way to age, intriguing insight from Down Syndrome has given insight into how disrupted nuclear architecture can push us down the wrong path. Down syndrome results from the triplication of chromosome 21 and is a leading cause of intellectual disability. However, Down syndrome is also a […]
