Updated cfDNA Nucleosomics Technology Upgrades our Epigenetic ClocksMarch 4, 2024A new style, novel functionalities, and a better overall product; we always want our smartwatches to employ the latest technology, and why not?! Now, a well-timed update involving cell-free DNA (cfDNA) nucleosomics-based technology provides for a significantly upgraded epigenetic clock, which may boost aging-based research. A punctual team led by Vladimir B. Teif (University of […]
TIME-Seq Flies When Constructing Cost-Effective Epigenetic ClocksFebruary 19, 2024If time drags and money disappears when looking at DNA methylation-based epigenetic clocks, you are “in time” to hear of a newly described efficient and cost-effective bisulfite sequencing approach! Time flies – but money does not – with “tagmentation-based indexing for methylation sequencing” or TIME-seq! An on-time team led by David A. Sinclair (Harvard Medical […]
An Evolutionary and Epigenetic Tour-de-force Links DNA Methylation and Mammalian AgingSeptember 11, 2023Have you climbed Mount Everest? Recorded a critically acclaimed album?? Written the great American novel??? These life-affirming feats of body and mind pale into insignificance when compared to the evolutionary and epigenetic tour-de-force reported in two recent papers based on mammalian DNA methylation datasets of colossal size and importance. An expeditionary force led by Steve […]
Bringing in “Young Blood” Persistently and Systemically Slows Epigenetic AgingAugust 22, 2023Be it a football team, a book club, or an epigenetics lab, bringing in “young blood” can seriously improve quality in the short term, but does this effect endure? Now, a heterochronic parabiosis study reveals that long-term exposure to young blood induces persistent slowing of DNA methylation-based epigenetic aging and extends healthy lifespans in mice! […]
Altered Chromatin Accessibility Shows Why Aging Stem Cells Don’t Know if They’re Coming or Going!August 13, 2023Once young and carefree, the passing years creep up on us all and bring so many responsibilities and places to be that we don’t know whether we are coming or going! A busy new study shows that the chromatin accessibility and gene expression alterations that occur during aging impact neural stem cells (NSCs) in much […]
