Embrace Your Age! Age-related H4K16ac Gains Protect Your Brain from Developing Alzheimer’s DiseaseMarch 19, 2018In our quest for the fountain of youth, we often find ourselves attracted to anything that will fight off the signs of aging. But now, the first genome-wide analysis of a specific histone modification in the brains of human patients affected by Alzheimer’s disease (AD) demonstrates that we should embrace the epigenetic changes that come […]
Cutting Through the Epigenetic Complexities Linking Aging and TumorigenesisMarch 16, 2018Writing your first grant proposal? Optimizing that tricky Western blot? Programming an old PCR machine? Only a few things are more complex than our current understanding of the epigenetic links between aging and tumorigenesis, but this has not stopped a few valiant labs from doubling down and busting a few paradigms while they are at […]
Old Fathers Pass on an Unwanted Aging DNA Methylation Profile to the Next GenerationMarch 1, 2018Great looks, a well-worn leather jacket, and a wide-ranging collection of old vinyl records represent great examples of inheritances that fathers happily pass on to their grateful children. However, new findings from the lab of Dan Ehninger (German Center for Neurodegenerative Diseases, Bonn, Germany) show that older dads can also pass on an intergenerational effect […]
Epigenetic Aging Analysis Suggests That TERT Isn´t the Anti-aging Target You Are Looking For!February 13, 2018This isn’t some sort of Jedi mind trick, we promise, but TERT may not be the anti-aging target you are looking for! TERT, or telomerase reverse transcriptase, plays an essential role in the elongation and maintenance of telomeres and as telomeres shorten with age, many surmise that activation of TERT represents an exciting approach to […]
Like a Fine Wine, Histone Variant H2A.Z Represses Memories and Accumulates with Age!February 6, 2018While aging works wonders for the taste of our ever-accumulating wine collection, the passage of the years is not as kind to our memories! To fully decipher the processes underlying learning and memory differences in the aging brain, the lab of Iva Zovkic at the University of Toronto Mississauga (Canada) recently expanded on past work […]
