Stem Cell Reprogramming – Leaner, Quicker, Cheaper, BetterJune 20, 2015“More for less” is a phrase that generally gets most people excited, and scientists trying to make induced pluripotent stem cells (iPSCs) are no exception. The reprogramming of somatic cells to generate iPSCs aims to bring patient-specific cell replacement therapies to the masses, but the process currently suffers from obstacles common to new technologies – […]
Nukes Aid Stem Cell Research in the HeartJune 20, 2015Researchers from the laboratory of Jonas Frisén at the Karolinska Institutet in Sweden have recently put radioactive carbon from nuclear bomb tests to good use, testing whether the adult human heart has the ability to repair itself. So how does that work? Well, a sharp rise in atmospheric radioactive carbon in the 1950-60s due to […]
Webinar: Advanced ChIP Normalization ControlsJune 17, 2015Abstract: Gene expression is regulated by a combination of transcription factor binding and the distribution of epigenetic modifications across regulatory regions. Much of what we know about the epigenome and gene regulation stems from our ability to determine the genome-wide distribution of histone modifications and transcription factors using chromatin immunoprecipitation followed by next generation sequencing […]
Webinar: Locus-Specific Biochemical Analysis of Genome Functions Using enChIP with CRISPRJune 17, 2015Abstract Elucidation of molecular mechanisms of genome functions such as transcription and epigenetic regulation requires identification of components mediating the genome functions. To this end, we recently developed the locus-specific chromatin immunoprecipitation (ChIP) (locus-specific ChIP) technologies to identify molecules interacting with a given genomic region of interest in vivo. Locus-specific ChIP consists of insertional ChIP […]
KeyGenes Helps Predict Differentiated Humans iPSCsJune 15, 2015Cells differentiated from embryonic stem cells are generally phenotypically immature, so identifying what cell type they are can be a bit like trying to figure out what exactly the picture your child drew for you in kindergarten is supposed to be. “That’s lovely darling but…” Luckily, for biologists at least, a team of Dutch researchers […]