Automated Chromatin Profiling Platforms Autopilot Patients to the ClinicNovember 22, 2021From human-free supermarket check-outs to autopiloted cars, the modern world is rapidly moving towards automation. In the most recent advance, a rabble of robotic researchers has applied related technological tricks to epigenetic assays to “autopilot” high-throughput chromatin profiling and provide a clinical tool that may support optimized treatment choices in leukemia patients. Specifically, a technology-driven […]
dCas9 Hinders DNA Methylation to Cast Off the Confounds from CausalityNovember 4, 2021Our day-to-day experiences provide a clear understanding of cause-and-effect; a lab mate’s birthday means cake for lunch, and cake for lunch means hours of hard work in the gym! While this cake-centric concept might be simple and easy to follow, the seemingly straightforward causal relationship between DNA demethylation and the upregulation of gene expression, much […]
Epigenetics Takes the Wheel as the Brain Mapping Project Gets Motoring!October 30, 2021It’s easy to get lost when motoring down the epigenetic landscape; thankfully, a group of cunning cartographers from the Brain Research through Advancing Innovative Neurotechnologies Initiative Cell Census Network (or BICCN for short) has generated single-cell maps to guide your voyage of the brains’ motor cortex. Although this epigenetic road trip may be too long […]
KLF4 Condensation Gets Your Epigenome in Shape with the Help of DNA MethylationOctober 18, 2021While juices and shakes may be nothing but a fitness fad for those looking to get into serious shape, liquid-liquid biomolecular condensation has washed away previous paradigms by highlighting its vital role in gene regulation and chromatin organization. Now, a rather fit new study has described how biomolecular drop-like condensates of the reprogramming factor KLF4 […]
Burn After Reading: m6A mRNA Reader YTHDF2 Helps Cancer Cells Manage Their Protein ProblemsOctober 11, 2021It turns out that the “burn after reading” strategy doesn’t just apply to the secret messages (and not-so-secret memoirs) of CIA analysts, it also helps keep cancer cells alive. In a new study, the lab of Gene Yeo at UCSD deciphered key vulnerabilities in a cancerous network, highlighting a role for the m6A mRNA reader […]