Nanofluidic Sorting and Analyzing of Single Methylated DNA Molecules in Real TimeMay 14, 2012Getting kids to line up single-file can be a challenge, but lining up single molecules for analyses can be just as frustrating. Now, researchers at Cornell report that they’ve done just that—they can line up single DNA molecules in a tiny channel in a nanofluidic device, sort them according to methylation state, then recover them […]
Variable Methylation Regions and Missing Heritability with Dr. Andrew FeinbergMay 10, 2012Dr. Andrew Feinberg discusses how epigenetics might be related to missing heritability of disease via variable methylation regions. This interview was shot on campus at Johns Hopkins University. Variable Methylation Regions and Missing Heritability So a conundrum in modern human genetics is how epigenetics might be related to missing heritability of disease, what’s commonly […]
HPV Integration Brings Cancerous Changes to the DNA MethylomeMay 9, 2012Vaccination against human papillomavirus (HPV) can protect against many forms of the virus, which can cause cervical cancer. But not everyone gets vaccinated, and there’s still a risk of becoming infected with an HPV type that the vaccination doesn’t cover. Early epigenetic events associated with HPV infection are still mysterious, so researchers in the United […]
Pregnancy-linked miRNA Cluster in Exosomes May Spark AdenomasMay 9, 2012We’ve all had things come back and haunt us—like our high school yearbook picture (the horror!). Now, researchers in Germany say they hypothesize that the same thing could happen with a chromosome 19 miRNA cluster. These miRNAs appear to dampen a mother’s immune response to a developing fetus, but the researchers think that this “immunomodulatory” […]
Virtual Poster Presentation: Comprehensive DNA Methylation Profiling of 3.7 million CpGs with the SureSelect Target Enrichment SystemMay 8, 2012What new technique reveals more information than methylation microarrays by detecting individual CpGs, increases throughput with reduced costs compared to Whole Genome Bisulfite Sequencing and reveals methylated regions undetected by RRBS and Me-Dip? Tune in to a virtual presentation delivered Dr. Kyeong Soo Jeong, R&D Scientist, Genomics Group, Agilent Technologies as he presents a poster that […]