Single-Cell Spatial and Multimodal Upgrades to ATAC-Seq Speed Up Your Chromatin InsightsOctober 9, 2022Need to get swiftly up to date with recent advances to the assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-Seq) technique? Well, slow down and read on for the latest single-cell spatial and multimodal updates to your chromatin toolbox! Our first study gives us a quick lowdown on Spatial-ATAC-seq, a technique to capture spatial chromatin […]
Multiomic Face-off Finds the Factors that Lead to Look-alikes!September 6, 2022Have you ever heard of someone bumping into their doppelgänger and wondered how the forces of biology conspired to make two unrelated people look alike? In a recent study, a few familiar faces took advantage of a photographer’s keen eye and a multiomic “face-off” to find those factors that lead two strangers to look alike! […]
eBook: Single-cell Methods in Epigenetics and GenomicsAugust 24, 2022Single-Cell methodologies can be the most comprehensive way to identify cell subpopulations with different transcriptome and epigenetic profiles within complex samples, eliminating the need for isolation strategies like FACS or magnetic sorting that could alter the biology due to sample manipulation. These methods are proving to be invaluable for Identifying novel cells that modulate response […]
Novel Multiomic Epigenetic Clock May Decipher How Epigenetic Aging Impacts Cell FunctionAugust 23, 2022Timely advances have demonstrated that significant changes to DNA methylation levels accompany the creaking knees, failing eyes, and changing tastes in music (!) associated with the human aging process. A well-timed study now builds upon these past studies to describe a multiomic-based approach with the potential to forge links between epigenetic aging and the gene […]
No Cells? No Problem! How Cell-Free DNA Methylation Profiles May Guide Cancer ManagementAugust 20, 2022When set the monumental task of studying how the epigenetic mechanisms underlying tumorigenesis, isolating a cell sample usually represents your first analytical port of call; however, research now suggests that liquid biopsies of a patient’s blood may provide a wealth of information from cell-free DNA. Furthermore, widening this approach to DNA methylation analysis may also […]
Multimodal Nanopore Profiling of Circulating Tumor DNAAugust 1, 2022The Oxford Nanopore (ONT) sequencing platform may have more modalities than a Swiss army knife. In a multimodal masterpiece of a new study, researchers now demonstrate how DNA methylation, copy number alterations, nucleosome footprinting, and fragmentation profiles derived from liquid biopsies of cancer patients can deconvolute cellular composition and identify cancer-specific methylation changes from circulating […]
Anchor-based Bisulfite Sequencing Sets Sail to Explore the DNA Methylome!July 10, 2022The anchor is a crucial part of any seaworthy ship of exploration, and after setting sail from your local CpG island, you’ll be glad you stowed anchor-based bisulfite sequencing (or ABBS) to keep your DNA methylation voyages firmly anchored to new and exciting regions of the methylome. Anchor-based bisulfite sequencing, which comes to you from […]
Location, Location, Location! – How Site-specific mRNA ac4C Acetylation Impacts TranslationJune 29, 2022Where you spend your time away from work – a lake-side cottage far from the hustle and bustle or a party pad in the bohemian part of town – is a crucial decision. Now, new research on roaming RNAs demonstrates that when you call the epitranscriptome your home, the age-old rule “location, location, location” also […]
Now In Print! – New Technologies Leave their Mark on Imprinting Control RegionsJune 19, 2022Genomic imprinting typically lets our parents leave their mark on our genomes; however, new technological advances are now allowing us to leave our mark on imprinting! The first of our epigenetic exposés that went into print reports on how multiple modalities uncovered complex epigenetic crosstalk that regulates allele-specific gene expression at potential imprinting control regions […]
EPIC Technique Infers Gene Expression from Cell-free DNA FragmentationMay 9, 2022It’s time to put down that well-thumbed copy of Homer’s Odyssey, as there is a new epic in town. Now, the “epigenetic expression inference from cell-free (cf)DNA-sequencing” (EPIC-seq) technique heroically enables gene expression analysis using a process known as “fragmentomics.” Circulating cfDNA comes as nucleosome-associated fragments that reflect the chromatin configuration in the cell of […]
