Radiation therapy usually works well against cancer, but some cells that survive the blast can divide and become unstable (cancerous) much later on, causing a relapse. Researchers initially thought that DNA hypomethylation was to blame for “delayed radiation-induced genomic instability,” but a new study in Epigenetics, August 2012 shows that, at least for embryonic stem […]
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Abcam EpiSeeker Assays Lead the Search for DNMT Knowledge
DNA methyltransferases (DNMTs) have been a trending topic in the epigenetics community for years because of their role in cytosine methylation. Studies that set out to pin down the precise function of DNMTs in various disease and developmental states often introduce more questions than answers. To get to the bottom of DNMT function, you need […]
EpiSeeker DNMT1 Inhibitor Screening Assay Kit
Product Overview: DNMT1 (DNA (cytosine-5)-methyltransferase 1) belongs to the DNMT family, responsible for methylation of CpG islands in the genome. DNMT1 preferably methylates cytosines located in hemimethylated DNA and it associates with DNA replication sites in S-phase. The selective inhibition of DNMT1 may lead to demethylation and expression of silenced tumor suppressor genes. Thus, the […]
EpiSeeker DNMT3B Inhibitor Screening Assay Kit
Product Overview: DNMT3B (DNA (cytosine-5)-methyltransferase 3B) belongs to the DNMT family, it is required for genome de novo methylation and it is essential for establishment of DNA methylation patterns during development. The selective inhibition of DNMT3B may lead to demethylation and expression of silenced tumor suppressor genes. Thus, the selective DNMT3B inhibitors could be a […]
EpiSeeker DNMT Activity Quantification Kit (Colorimetric)
Product Overview: DNMT (DNA methylases) is a family of enzymes responsible for the addition of methyl groups on the cytosine ring at the 5′ position of a CpG dinucleotide. The DNMT family is required for the establishment and maintenance of DNA methylation patterns. EpiSeeker DNMT Activity Quantification Kit (Colorimetric) (ab113467) allows the user to colorimetrically […]