Not to get all “Oprah”, but sometimes, you need to let go of unstable elements in order to enhance your life. Researchers now report that this drama unfolds at the DNA level too. Here’s what they found: an unstable nucleosome sitting smack dab in the center of an enhancer can get kicked off to make […]
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Search Results for: ChIP
The Secret Life of 5-Azacytidine
5-azacytidine has been in the public eye for quite a while now, and it’s been widely known as a powerful demethylating agent in clinical trials for cancer. So you can imagine our surprise when a new publication in Epigenetics caught 5-azacytidine also living a secret life of reorganizing histone modifications…lots of them. Researchers from UC […]
SCAN-ing For Chromatin Gold
If you run enough tedious ChIP experiments, it feels like you might as well be panning for gold back in the 1800s; doing a lot of work for a few nuggets of data. Luckily some technological wizards at Cornell University have your back and are working on a new system called SCAN (Single Chromatin Analysis […]
Epigenetic Drugs: More Than Hype in the Pipeline
It’s 10 p.m. on a Friday night, and you’re still stuck in the lab doing ChIP assays. As the piercing whine of the sonicator frays your last nerve, you ask yourself again, “Why did I go into epigenetics research…why couldn’t I have chosen something simpler and more straightforward (like rocket science)?” At times like these, […]
Getting RIPped: miRNA Target ID Workout Delivers
As former bodybuilder turned California Governator, Arnold Schwarzenegger, once said, “Great abs are made in the kitchen…” That may be, but when it comes to epigenetics research, great abs are made by great labs and suppliers, and they’re put to work in immunoprecipitation applications like RIP Chip. Recently, Anke van den Berg and colleagues at […]