eBook: Single-cell Methods in Epigenetics and GenomicsAugust 24, 2022Single-Cell methodologies can be the most comprehensive way to identify cell subpopulations with different transcriptome and epigenetic profiles within complex samples, eliminating the need for isolation strategies like FACS or magnetic sorting that could alter the biology due to sample manipulation. These methods are proving to be invaluable for Identifying novel cells that modulate response […]
eBook: Epigenetics of CannabisJuly 21, 2022Changes in epigenetic regulation are hallmarks of the transition from normal to diseased cells. Exploration of the role of epigenetics in those who may use Cannabis, or related products such as THC or CBD, has proven to be informative for better understanding of their potential effects. In this EpiGenie ebook, we present summaries of several […]
eBook: Epigenomics of SpermJune 9, 2022Some of the most interesting and important epigenetic phenomena occur in sperm. In addition to passing genetic paternal information, experiences and exposures can be encoded in the epigenome and inherited as well. In this EpiGenie ebook, we present summaries of several studies on exploring the role of epigenetic processes in sperm biology. They are divided […]
EpiGenie Guide: Chromatin ShearingMarch 6, 2020ChIP-Seq has transformed the field of epigenetics, providing unprecedented resolution and coverage for surveying protein- DNA interactions. Powerful, high-throughput sequencing is credited with most of the benefits, but there’s a lot more that goes into ChIP-Seq than sequencing. Chromatin shearing is one of the first critical steps in the ChIP-Seq workflow. Depending on your approach, […]
ChIP 101: Beginner’s Guide to ChIP AssaysJuly 24, 2019Become a ChIP Assay Expert! The chromatin immunoprecipitation (ChIP) assay is one of the best ways to study the association of DNA-binding proteins with chromatin and the localization of histone modifications throughout the genome. But ChIP assays take time to master. Our friends at Active Motif have put together this free ChIP 101 eBook that […]
eBook: NeuroepigeneticsJuly 4, 2019It’s become increasing clear that epigenetic mechanisms have a unique role to play in the brain. From neurodevelopment, to memory, to brain function epigenetic mechanisms seem to be very important. These mechanisms are also frequently perturbed in neurological disorders. In this ebook, we’ve assembled summaries of research related to uncovering the many roles of epigenetics […]
eBook: Cancer and EpigeneticsMay 15, 2019Changes in epigenetic regulation are hallmarks of the transition from normal to cancerous cells. Exploration of the role of epigenetics in cancer has proven to be informative for better understanding both cancer and epigenetic mechanisms. In this EpiGenie ebook, we present summaries of several studies on exploring the role of specific epigenetic processes in cancer. […]
eBook: Aging and EpigeneticsJune 8, 2018This eBook explores various levels at which aging and epigenetics are related. Assembled are summaries of studies exploring specific questions regarding the epigenetic basis of aging and aging-related conditions. They are divided into four chapters: 1. DNA Methylation Epigenetic Clock 2. Anti-aging 3. Alzheimer’s Disease 4. Stem Cells
eBook: Key Chromatin Players | H3K27December 6, 2017Histone H3 lysine 27 (H3K27) is one of the most studied histone modifications with a complex biological role. Trimethyaltion of K27 is a hallmark of repressed transcription, while acetylation is associated with active transcription. Recent work has supported these roles as well as provided evidence for novel functions. This ebook covers the basics of H3K27 modifications, their role […]
eBook: Key Chromatin Players | H3K4June 24, 2017Histone H3 lysine 4 (H3K4) is one of the most widely studied histone modifications. Acetylation (H3K4me) and various degrees of methylation (H3K4me) of this residue are involved in countless processes. In general, H3K4 modifications are associated with active transcription. Recent research has further characterized these roles as well as identified new functions. This ebook covers […]
