EpiGenie Book Reviews: EpigeneticsMarch 11, 2013If you’ve spent any time browsing the EpiGenie site, then you already know that we find epigenetics pretty interesting. So, of course any book with the title of Epigenetics is going to grab our attention. Epigenetics edited by Jörg Tost, gathers information from several top scientists working in various facets of epigenetics to assemble a […]
Correcting Brain Tissue Heterogeneity with DNA MethylationFebruary 28, 2013A few weeks ago, we highlighted some great work that has been very useful in helping correct for heterogeneous cell populations in blood. Now, we’ve just got wind of a clever new bioinformatics tool to correct for heterogeneity in the brain. Researchers have studied DNA methylation in brain tissue to see if there’s an association between that modification and […]
EpiGenie Reviews: RNA Interference and Viruses – Current Innovations and Future TrendsFebruary 11, 2013RNA interference (RNAi) was first discovered in 1998 and has sparked new innovations and novel research tools for biological research ever since. RNAi has the scientific community buzzing because of it’s huge potential to tackle some of our most dreaded viral infectious diseases, like hepatitis C virus (HCV) and human immunodeficiency virus (HIV). But there […]
The Epigenetics of Organ TransplantationJanuary 31, 2013Dr. Daniel Salomon discusses the state of organ transplants, what obstacles exist, and how epigenetics might be central to improving long-term health in patients. The Challenges in Transplantation My background is in transplantation medicine, transplantation immunology. And my interests are to change the way we manage patients. There’s a huge series of challenges right […]
Visualize Histone Modifications in Single Cells? Yes You Can.January 18, 2013ChIP has been a dear friend to researchers studying histone modifications for years. But, just like most friends, it has its imperfections too, particularly when it comes to sensitivity. On its best day ChIP is about as sensitive as Mr. Trump and just like The Donald, it can be temperamental. So we were excited to […]
Making Sense of the Grade: ChIP Validation TerminologyJanuary 17, 2013Antibody vendors have been hard at work to offer antibodies that are suitable for applications like ChIP. Usually these antibodies have been used successfully in peer-reviewed publications. In many cases they’ve been validated internally by an R&D team, and in some cases, each lot may be validated to work in ChIP applications. The tricky part […]
Top Epigenetics & ncRNA Conference Picks for Winter 2013December 27, 2012We’re on the verge of 2013. For those of you who want to up your epigenetics research game and have some fun in the process, we’ve got conferences you should definitely check out. The year starts off a little quiet on the numbers front, but the quality more than makes up for it. January […]
5hmC Analysis TimelineDecember 10, 2012EpiGenie has probably covered developments in 5hmC more than any topic the last couple of years, so we’ve compiled this timeline for you. Scroll along to see what you may have missed if you’ve been out of the loop or lab for a sabbatical.
MNase-Seq Produces High Resolution Nucleosome Positioning MapsNovember 27, 2012Nucleosomes don’t have GPS, so how do they know where to go? Are they haphazardly strewn across the genome or is there some logic to it? Researchers now say they have some answers. They found that DNA sequence and DNA-binding proteins play roles in determining where nucleosomes end up, and that most nucleosomes are more […]
Lentiviral Vectors Can Cause Epigenetic ModificationsNovember 20, 2012Stem cell programming has been buzzing the last few years and with recent work suggesting that epigenetic and ncRNA factors are manipulative enough to star in TV drama, we expect the excitement to continue. But according to a recent report, researchers may need to keep close tabs on how the very methods they use to […]
