EpiGenie 5hmC Technology GuideOctober 31, 2012A couple of years ago, researchers keen to analyze 5-hmC had a couple of options, but those early approaches couldn’t quite satisfy all of their increasing demands. Fast-forward a bit and it’s a very different story. Today there’s a plethora of options, each with its own strengths and weaknesses. As a result, one of the […]
This Stem Cell Reprogramming is Made Possible with Generous Support from Histone H3.3October 30, 2012Some people dress up their pets in clothes so that they will look more like their human owners. Turns out, a similar thing happens in the nuclear transfer process to make stem cells. Jerome Jullien and colleagues in 2012 Nobel laureate John B. Gurdon’s lab (along with a number of other great researchers in France […]
Three Ways to Get Intimate with Epigenetic MarksOctober 24, 2012The days of dealing with regional estimates of epigenetic marks like histone modifications and DNA methylation are just about behind us. That’s right, the maps that lie ahead will be less Thomas Guide and more GPS. Drs. Gabriel Zentner and Steve Henikoff recently took some time off from being all-star cancer researchers and pulled together […]
Webinar: Early Life Determinants of Mental Health – Epigenomic Mechanisms with Dr. Patrick McGowanOctober 3, 2012Dr. Patrick McGowan discusses the impact early-life events can have on our epigenomes in this recorded webinar. This webinar is brought to you with support from Porvair Filtration Group. Check out their line of innovative ChIP kits and reagents at chromatrap.com Abstract Human epidemiological studies and studies of animal models provide many examples by which […]
Webinar: Epigenetics of Autism – The Interface Between Genetic and Environmental Risks with Dr. Janine LaSalleOctober 3, 2012Dr. Janine LaSalle discusses some of the potential epigenetics mechanisms involved in autism spectrum disorders in this recorded webinar. This webinar is brought to you with support from Porvair Filtration Group. Check out their line of innovative ChIP kits and reagents at chromatrap.com Epigenetics of Autism Autism is an increasingly common disorder of complex etiology, […]
The State of Epigenetic EditingSeptember 27, 2012If the field of epigenetics is heading into adolescence (rapid growth, disruptive, with occasional data tantrums), the arena of Epigenetic Editing (gene-specific rewriting of epigenetic marks) is more zygotic than anything, with far more questions than answers. But the concept of systematically manipulating epigenetic marks to modulate gene expression is injecting some air back into […]
Bromodomain Inhibitor is the Male Contraception for the Ladies’ MouseAugust 22, 2012Mice from your backyard to Paris are buzzing with excitement after a team of scientists at Baylor may have paved the way for them to “mingle” with fewer consequences. The research team, led by Martin Matzuk, set out to explore ways to target, BRDT, a testes-specific, and bromo-domain containing protein that plays a key role […]
Non-Coding RNAs and Drug AddictionJuly 31, 2012Although a lot of behavioral studies are out there on drug addiction, no one really knows how addiction develops at the molecular level. A new review by researchers in Miami describes lots of evidence from more than 80 studies suggesting that non-coding RNAs, such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), might have a […]
Pol II Transcription Slows at 5-Formylcytosines (5caC) and 5-Carboxylcytosines (5fC)July 31, 2012It’s summertime—a time when you just want to take things slow. Researchers now report that 5-formylcytosines (5fCs) and 5-carboxylcytosines (5caCs) like to slow things down, no matter what the season. They say that these mods put the brakes on RNA Pol II transcription and make it less specific. Sure, researchers have known about 5fC and […]
DNA Methylation Addiction Keeps Cancer Cells AliveJune 13, 2012Addictions are so strong that some people think they can’t live without them. For cancer cells, that’s actually the case. Cancer cells’ DNA methylation addiction actually keeps them alive, according to a group of California researchers. Altered DNA methylation is just one of many changes that go down when a cell becomes cancerous. The researchers […]
