Get In Tune with Chromatin: Abcam High Sensitivity ChIP KitsSeptember 3, 2014Today’s epigenetics researchers need to squeeze every last bit of detail from the chromatin immunoprecipitation (ChIP) experiments they run. That’s why Abcam launched their new High Sensitivity ChIP kits; to help bench scientists stay tuned in to what’s going on with the chromatin in their samples. Abcam High Sensitivity ChIP Kits sport some pretty nifty […]
Chromatin Never Forgets to Stay in the LoopSeptember 3, 2014While DNA has long been thought of as the molecular sheriff of inheritance, the epigenome continues to unravel it’s mystery in a western film style, with chromatin as the lasso wielding cowboy that never lets past transgressions slide. It seems that the pericentric heterochromatin (PCH) gang has gone and looted chromatin of it’s transcriptional treasures by some organized crime. […]
3D Epigenome Folding ModelsAugust 21, 2014Much like 3D pictures enhance the illusion of depth of picture perception, polymer physics can enhance the depth of organization of epigenomic landscape in topologically associated 3D loop domains. Eukaryotic chromatin is organized into topologically associated epigenomic domains. A team of French researchers led by Daniel Jost recently unveiled a new approach for modeling epigenomic […]
Online Stem Cell Diploma from University of Ulster 2014August 13, 2014The University of Ulster is offering an entirely online, postgraduate diploma course in Stem Cell Biology and it’s starting soon. The course is designed to allow students to break into, or advance in a career in the stem cell field. They’ve assembled a panel of international stem cell industry experts advising on the course content […]
Gazing at Your Local Epiproteome with CRISPR-ChAP-MSAugust 4, 2014For those of you who were thinking the CRISPR/Cas9 system was just limited to genome editing, think again because the story just got a new twist. Almost like combining the bullet speed of Superman with the hi-tech gadgets of Batman, Alan Tackett and colleagues come up with a new tool to look at all the […]
Hold Your ‘breadth’ – H3K4me3 Domain Size MattersAugust 1, 2014Apple may have finally thrown the gloves off in the race for larger screens, but it appears that this is old news for cells, who have been elevating the status of important genes for years by marking them with large billboards of H3K4 tri-methylation. These genes then get the VIP treatment from cellular machinery ensuring “enhanced […]
Webinar: Using CRISPR/Cas9 Technology for Editing Genes in Haematopoietic Cells and MiceJuly 29, 2014Presented by: Dr Marco Herold, Laboratory Head, Molecular Genetics of Cancer Division, The Walter & Eliza Hall Institute of Medical Research Abstract: The CRISPR/Cas9 technology provides an easy and rapid way to edit genes in vitro and in vivo. Initial experimental strategies utilized a transient transfection approach to modulate genes in vitro, but this proved […]
Webinar – Bringing ChIP Seq Data into Focus: Advanced Normalization StrategiesJuly 23, 2014If you’ve ever struggled to make sense of your ChIP Seq data, then check out this webinar presented by our colleagues at Active Motif, to get some ideas on how to bring some order to the chaos of ChIP-seq. Presented by Brian Egan, Ph.D, Epigenetic Services Manager at Active Motif Normalization of ChIP-seq Data Today, […]
Accelerating Histone Modification DecryptionJuly 23, 2014Unlike some reality show marriages that crack under the media spotlight, the union of automation and big data is still going strong, especially when it comes to cataloging histone post-translational modifications (PTM). Researchers from Princeton University show off a new systematic approach for figuring out just what all those histone PTM combinations are up to […]
Chromatin Packaging in Embryonic Stem Cells and SpermJuly 16, 2014Fitting all that chromatin into a tiny package is no easy ordeal, especially when pristine nuclear architecture is so crucial to things like cancer prevention. In order to learn more about the chromatin packaging of mouse embryonic stem cells (ESCs) and sperm, a team from the University of Massachusetts Medical School laid out some high-resolution nucleosome and transcription factor […]