A Perfect Harmony: Orchestrating Joint Chromatin Conformation and Methylome Mapping in Single CellsOctober 7, 2019If a better understanding of gene regulation is music to your ears, then tune in for the latest developments in single-cell epigenomics. It is well established that both DNA methylation and higher-order chromatin structure play crucial roles in development, differentiation and disease, and there are readily available technologies for both (whole-genome bisulfite sequencing and chromatin […]
Gut Microorganisms Make Epithelial HDAC3 Work to their RhythmOctober 7, 2019While many of us prefer the sound of silence, others feel the need to inject a little rhythm into their everyday lives; but how do you do it? Spinning a few records at home, moving to the beat at Samba lessons, or do you use the microorganism-mediated activity of Hdac3 in your gut?! While researchers […]
Webinar: The Epigenetics of the Exposome and Aging – Paul G. ShielsOctober 2, 2019Don’t miss this great webinar detailing some of the latest discoveries about the role of epigenetics in aging. Aging results in a gradual and progressive loss of physiological functions and physical abilities over time. Overcoming the growing burden of age-related issues is one of the greatest challenges facing modern society. These issues are leading to […]
Sherlock Genomes: Stimulation Leaves Epigenetic Evidence Behind in NeuronsSeptember 30, 2019Even the most careful criminals leave some kind of evidence; a fingerprint or a strand of hair can be enough for a clever investigator to link them to the scene of the crime. Although it’s far from an open and shut case, new research in mice shows that the epigenome of neurons contains chromatin clues […]
The Tn5 Transposase Takes Single-cell ChIP-Seq to the Next LevelSeptember 18, 2019It’s never good to see someone lagging behind the rest, but while stepwise developments to single-cell chromatin immunoprecipitation and subsequent parallel sequencing techniques (ChIP-seq) have led to gradually improved yields and increased sensitivity with reduced numbers of cells since the first report of a single-cell ChIP protocol, we still lack widely-applicable and low-cost methods to […]
Maladaptive Memories are Mediated by Methylated Histones and ΔFosB in the Mouse HippocampusSeptember 10, 2019The air is starting to get crisp, the first few leaves are changing color and you can suddenly buy pumpkin-spice everything – these contextual cues can only mean one thing; you’d better start studying for your midterms! But wait, you haven’t had to worry about exams for years… Thanks to your hippocampus and epigenetics, environmental […]
LADL-ing Up a New Optoepigenetic Chromatin Looping TechniqueAugust 12, 2019For your daily serving of epigenetics brain food, look no further than the entwined spaghetti-like chromatin. Although it may look like a bowl full of chaos, there are distinct domains and long-range genomic interactions that function in a variety of regulatory roles. A team at the University of Pennsylvania (USA) led by Jennifer Phillips-Cremins and […]
ChIP 101: Beginner’s Guide to ChIP AssaysJuly 24, 2019Become a ChIP Assay Expert! The chromatin immunoprecipitation (ChIP) assay is one of the best ways to study the association of DNA-binding proteins with chromatin and the localization of histone modifications throughout the genome. But ChIP assays take time to master. Our friends at Active Motif have put together this free ChIP 101 eBook that […]
Mitochondrial Memes: How the Powerhouse of the Cell also Drives Epigenomic AlterationsJuly 12, 2019The appreciation of the mitochondrion as “the powerhouse of the cell” has become as culturally pervasive as some of our favorite memes; however, a powerful new study now shows that signals deriving from this double-membrane-bound ATP-generating organelle represent a major driving force behind alterations to the epigenome. A talented team of researchers from the lab […]
Single Cell ChIP-Seq Seeks Out Cellular SubgroupsJuly 3, 2019When it comes to love, being single has its pros and cons. This is also true for cells, single cells give a lot high-resolution picture, but it’s often very difficult to get enough material. While other single cell methods have flourished with low inputs, studies of the heterogeneity of chromatin states by single cell chromatin […]
