EpiGo-KRAB: A New, Live-action Tool to Edit and Visualize Heterochromatin Formation in Living ColorJanuary 26, 2021Like any live-action remake, vibrant colors are essential for a new epigenetic editing tool that simultaneously introduces H3K9me3 at hundreds of targeted loci while also allowing for HD visualization of the heterochromatic results. Now, let’s meet the stars of this show that were cast by a team led by Hanhui Ma from ShanghaiTech University. H3K9me3 […]
Sperm Throw “Three-pointers” to Ensure Transgenerational Epigenetic InheritanceJanuary 26, 2021In the game of transgenerational epigenetic inheritance, many labs have been searching for a slam dunk. Now, in a game-changing new article, ballers from the laboratory of Michael K. Skinner (Washington State University, Pullman, WA, USA) provide a play-by-play of how teamwork between non-coding RNA expression, DNA methylation, and histone modifications allows rat sperm to […]
NanoNOMe Combines Nanopore and NOMe-seq to Mine the Allele-specific EpigenomeJanuary 18, 2021Gnomes are small magical creatures that mine for treasures, so you might wonder if a nanoNOMe is an even tinier being. Well actually it’s a new molecular technique, but its applications are nothing short of magical. Several methods have been developed to probe DNA methylation, transcription factors, and chromatin state simultaneously. Many are based on […]
Reprogramming Helps to “Turn Back Time” on the Epigenetic Clock and Restore Lost VisionDecember 14, 2020Back in the days of big hair and masses of leather, Cher wanted to “turn back time” if she could find a way! Well, get your stockings and suspenders ready and head for the docks, as her eighties “vision” may be on the cusp of coming true with the help of epigenetic reprogramming! Specifically, resear-Cher-s […]
Blame the Brain on Cocaine: DNA Methylation Alters 3D Chromatin TerrainDecember 8, 2020Although studies of DNA methylation and its impact on chromatin architecture leave us with quite the buzz, this latest one adds a bit of cocaine to the mix to give it an extra kick. This stimulating study found cocaine use reduced DNA methylation at a key gene to change CTCF binding and alter 3D chromatin […]
Epigenetic Silencing of the Y-chromosome Controls the Extent of Male ToxicityDecember 7, 2020While “toxic masculinity” may seem intimately linked to the human species, the fruit fly Drosophila has come to show us that their Y-chromosome acts as a source of genomic male “toxicity” that epigenetic silencing keeps in check. Specifically, we know that the formation of silent heterochromatin domains during development represses the activity of transposable elements […]
Histone Methylation Takes Center Stage in the Genetic Tale of Transgenerational Epigenetic InheritanceDecember 4, 2020While DNA methylation and distinct RNA species have hogged the limelight in the ongoing tale of paternal epigenetic inheritance, a genetic mouse model now casts histone methylation as a leading player in this gripping transgenerational story. A previous study led by Sarah Kimmins (McGill University, Montreal, Canada) found that reduced H3 lysine 4 dimethylation (H3K4me2) in […]
How I Met Your Mother: DNMT3A from Mom Leaves its Mark on Dad’s Genome in the Early EmbryoNovember 24, 2020While stories of Mom meeting Dad often leave their mark on a family, and sometimes a nation, the plot has now thickened thanks to new findings showing that Mom’s DNMT3A leaves its mark on Dad’s genome in the early embryo. DNA methylation in the male germline undergoes massive changes during preimplantation. High paternal DNA methylation […]
Turning the Spotlight on Extraordinary Epigenetics ContentNovember 13, 2020Our sponsors help keep the lights on, the Wi-Fi humming, and our epigenetic content flowing to your screens each week. And while we may be a tad biased, we want to turn the spotlight on the range of highly useful and always educational epigenetics content from these websites that you should check out! Dovetail Genomics […]
Special Multiomics Feature: Combinatorial DNA Methylation and Chromatin Assays Serve Up New InsightNovember 9, 2020Combinations of old favorites can be even tastier than the sum of their parts. Who doesn’t leave peanut butter and jam, chips and dip, and DNA methylation and chromatin assays? While they sound appetizing, those last two aren’t quite as easy to get together. Many assays have been developed in the past to combine ChIP […]
