SIF-seq Sifts Out Stem Cell Enhancer GoldApril 10, 2014Searching for functional enhancers is sort of like panning for gold; there is enormous potential for riches, but the task is akin to finding a needle in a stack of needles. A team from the Berkeley National Laboratory decided to apply their own gold rush-style, enhancer mining techniques to develop a new method for the discovery of functional enhancers aided […]
Histone Code Tips the Scales of DevelopmentMarch 31, 2014All of life is a balancing act. Whether you’re walking the tight-rope in a circus, or the epigenome regulating gene expression its all about treading a fine line. Recently a team from the Institute of Medical Biology in Singapore found, while examining frog development, that there is an optimal ratio of the repressive histone H3 and […]
Transgenerational Epigenetic Inheritance TimelineMarch 17, 2014Molecular inheritance is what genetics is all about, so here we highlight some examples where the epigenome plays a key role in inheritance.
Histone Acetyltransferase Circumin Eases Neuropathic PainMarch 17, 2014There’s definitely not much “gain” in Neuropathic Pain, but recently some Histone Acetyltranferases (HATs) have begun to show great promise in the clinic. This includes circumin, which is used to treat a number of conditions like Alzheimer’s, Cancer, Arthritis and Neuropathic Pain. Circumin is a (p300/CREB-binding protein (CBP)) inhibitor of HAT activity, but the biological mechanisms for […]
EpiGenie Book Reviews: Epigenetics by L. ArmstrongMarch 14, 2014After working on some of the UK’s first embryonic stem cells and developing the world’s first cloned human embryos, Lyle Armstrong turned his attention to the creation of a useful text that would benefit the epigenetic novice as well as the seasoned investigator. With a number of groovy figures and illustrations, they key concepts of […]
Webinar: Genetic Analysis of the Physiological Roles for lncRNAs in DevelopmentMarch 8, 2014Loyal A. Goff, Ph.D presents his research on: Genetic Analysis of the Physiological Roles for lncRNAs in Development Abstract: Many studies are uncovering functional roles for long noncoding RNAs (lncRNAs), yet few have been tested for in vivo relevance through genetic ablation in animal models. To investigate the functional relevance of lncRNAs in various physiological […]
Great Deals on Insight Pharma’s Epigenetics ReportMarch 5, 2014Our friends at Insight Pharma Reports created an exclusive deal, just for EpiGenie readers: Get 25% off of their new epigenetics report. This is a must have for anyone that needs to stay in tune with the epigenetics research market. There, now don’t you feel special? Epigenetics: Emerging Targets, Available Technologies, Expert Interviews, and an […]
Go Into the Light With Promega HDAC-Glo™ 2/IIa AssaysFebruary 18, 2014Searching for that next great HDAC inhibitor can be a grueling task, but now the R&D team at Promega has just introduced the HDAC-Glo™ 2 and IIa Assays to make your HDAC screening life a whole lot better. Just like the rest of the HDAC-Glo™ Assay family, the HDAC-Glo™ Class IIa and HDAC-Glo™ 2 Assays […]
NOMe-Seq Secrets RevealedFebruary 17, 2014You’ve read the NOMe-seq (Nucleosome Occupancy and Methylome sequencing) papers. Seen the splashy advertisements. Now, we’ve consulted with the experts at Active Motif to get the inside scoop on how to get started, and get the most out of your NOMe-seq experience. NOMe-Seq was originally published and developed by researchers in the Peter Jones lab […]
Environmental Epigenetics TimelineFebruary 11, 2014Thanks to growing interest from the general public, environmental epigenetics is a red-hot topic with no signs of cooling off anytime soon. We’ve certainly covered our fair share of research with an environmental slant to it, so if you want to review, research, or just plain get up to speed on the subject, these articles […]
