Environmental Epigenetics TimelineFebruary 11, 2014Thanks to growing interest from the general public, environmental epigenetics is a red-hot topic with no signs of cooling off anytime soon. We’ve certainly covered our fair share of research with an environmental slant to it, so if you want to review, research, or just plain get up to speed on the subject, these articles […]
Clinical Epigenetics TimelineFebruary 10, 2014The underlying goal for most epigenetic research projects is to eventually lead to a therapeutic clinical application. Here we provide a history of clinical epigenetic advances in this interdisciplinary field as told through our articles and Conference Highlights.
Epigenetics of Cancer TimelineFebruary 9, 2014Epigenetic mechanisms have been studied in cancer for decades. Unfortunately, we haven’t been around that long, but check out these great articles that capture the recent history of epigenetic breakthroughs in cancer.
Evolution of Advanced Sequencing TimelineFebruary 7, 2014In a few short years. advanced sequencing has become nearly ubiquitous. Here we provide a history of how emerging sequencing technologies have driven epigenetic research and understanding.
Capture-C Catches Chromatin ContortionsFebruary 5, 2014Chromosome Conformation Capture (3C) is a cool technique that has lead to more spin-offs than the CSI TV franchise. This technique has been used at enhancers, silencers, boundary elements, and promoters at the individual loci level. But now a cunning team of researchers from Oxford University (UK) have just shown how to take it to an ‘omic level’. Here’ […]
Zymo-Spin™ ChIP Kits Give Chromatin Immunoprecipitations the Run-aroundFebruary 5, 2014After an extensive development and beta-testing process, the innovators at Zymo Research have unveiled the new Zymo-Spin™ ChIP Kit, which provides a whole new twist to standard chromatin precipitations. Special Discount to EpiGenie Readers: Get 20% OFF and a free “Blame It On My Epigenetics” T-shirt with every purchase of Zymo-Spin™ ChIP Kit (Catalog No. […]
Three Dimensional Chromatin & DNA Replication with Dr. David GilbertFebruary 3, 2014Dr. David Gilbert discusses the ins and outs of 3-D chromosome folding, DNA replication and the highly dynamic cell nucleus. 3-D Chromatin and DNA Replication There’s no question. The thing that I’m most excited about is the uncanny alignment between three dimensional chromatin confirmation maps and replication timing. The alignment is the greatest alignment that […]
Webinar: Mechanisms of Epigenetic Regulation in Stem Cells and DevelopmentJanuary 31, 2014Dr. Alexander Meissner discusses the roles of epigenetic mechanisms in stem cells and development. Cytosine methylation in mammals is an epigenetic modification that is largely restricted to CpG dinucleotides and serves multiple critical functions including stable repression of target promoters, maintaining genomic integrity, establishing parent-specific imprinting patterns, and silencing endogenous retrotransposon activity. In somatic tissues, […]
Up In Smoke: Nicotine’s Epigenetic ConsequencesJanuary 22, 2014As anyone who has tried to kick a pack-a-day cigarette habit can attest, nicotine is bad news. The jitters and surly attitude are bad enough, but according to a new investigation, fetal nicotine exposure also does some pretty insidious epigenetic damage. Daniel Hardy and a talented team Western University (Canada) have revealed a chromatin mechanism that […]
The Next Steps in Chromatin Contact Analysis with Dr. Gerd BlobelJanuary 20, 2014Dr. Gerd Blobel discusses emerging techniques for visualizing the interactions of RNAs and chromatin. The Future of Chromatin Contact Analysis So there are other approaches that people are taking, which is: you use FISH, for example, Fluorescent In Situ Hybridization. And this is a method that can be used to validate interactions that have been […]
