The IsomiR Comsos: Population and Gender DependanciesSeptember 17, 2014While microRNAs have been generally thought of as very homogenous little genomic modulators, some new studies are finding that there is actually an entire miRNA cosmos out there with slight variations that are relevant to gender and population differences in mammals. Over at Thomas Jefferson University, Isidore Rigoutsos and his colleagues have already seen some pretty […]
Webinar: “Precision Mapping”- High Resolution Mapping using ChIP-exoSeptember 12, 2014“Precision Mapping” – High Resolution Mapping Using ChIP-exo Presented by: Bryce Alves Ph.D., Research Scientist at Active Motif Abstract: Transcriptional regulation is a complex mechanism that involves changes in epigenetic modifications, transcription factors and cofactors, and chromatin structure. Loss of controlled transcription is often found in various human diseases, such as what is seen in […]
Online Stem Cell Diploma from University of Ulster 2014August 13, 2014The University of Ulster is offering an entirely online, postgraduate diploma course in Stem Cell Biology and it’s starting soon. The course is designed to allow students to break into, or advance in a career in the stem cell field. They’ve assembled a panel of international stem cell industry experts advising on the course content […]
Non-Watson-Crick Base Pairing in the miRNA Seed RegionAugust 12, 2014First epigenetics knocked Mendel off the high horse of simple inheritance and now it’s taking a shot at Watson and Crick. It seems that not even base-pairing is safe these days, with microRNA targeting demonstrating that it is anything but simple. In its latest political statement this member of the non-coding party has been caught […]
Webinar: Using CRISPR/Cas9 Technology for Editing Genes in Haematopoietic Cells and MiceJuly 29, 2014Presented by: Dr Marco Herold, Laboratory Head, Molecular Genetics of Cancer Division, The Walter & Eliza Hall Institute of Medical Research Abstract: The CRISPR/Cas9 technology provides an easy and rapid way to edit genes in vitro and in vivo. Initial experimental strategies utilized a transient transfection approach to modulate genes in vitro, but this proved […]
Webinar – Bringing ChIP Seq Data into Focus: Advanced Normalization StrategiesJuly 23, 2014If you’ve ever struggled to make sense of your ChIP Seq data, then check out this webinar presented by our colleagues at Active Motif, to get some ideas on how to bring some order to the chaos of ChIP-seq. Presented by Brian Egan, Ph.D, Epigenetic Services Manager at Active Motif Normalization of ChIP-seq Data Today, […]
5′ UTR miRNA TargetingJuly 21, 2014The nightly news lately makes it seem like the world has gone upside down, and now we’ve got some science to back it. Honglei Zhou and Isidore Rigoutsos from Thomas Jefferson University recently revealed that mammalian miRNA targeting doesn’t always limit itself to 3′ miRNA action. It now seems that in addition to the traditional 3’UTR […]
Reaction Biology Scores NIH Grant for Epigenetic Drug DatabaseJuly 11, 2014Epigenetic databases are one of of our favorite futuristic tools and now a time traveling crew from Reaction Biology Corporation (RBC) land a grant from the National Center for Advancing Translational Sciences (NCATS) to create an impressive database of epigenetic drug interactions. The team at RBC is undertaking a colossal effort examining a library of 1,400 compounds, including almost every FDA approved drug. […]
An Introduction to Epigenetic Editing with Dr. Marianne RotsJune 23, 2014Dr. Marianne Rots, Professor of Molecular Epigenetics and Head of Epigenetic Editing Laboratory at University of Groningen, Netherlands provides an informative overview of the current state of epigenetic editing approaches. Intro to Epigenetic Editing Epigenetic editing exploits the two main characteristics of epigenetics. On the one hand, epigenetic marks are heritable. This means the epigenetic […]
Webinar: The Good, the Bad and the Ugly: Getting Reliable ChIP Data From Difficult SamplesJune 19, 2014Johanna Samuelsson Ph.D., Senior Research Scientist at Active Motif covers some techniques to get killer data, even when your samples don’t make it easy. ChIP Overview I’m going to talk about chromatin immunoprecipitation, not necessarily focusing on all the specific details, but more the challenges with the technique, and those tricky samples that many of […]