Products

We know you'd rather be spending your time discovering some novel disease mechanism rather than purchasing, preparing, optimizing, calibrating and validating the reagents for your lab protocols, so check out these solutions for epigenetics research from our friends at the tool companies. Sure they may cost a little more than the homebrew, but how can you put a price on your time?

DNA Methylation
Chromatin
Non-Coding RNA
Vendors

5-hmC Detection

5-Hydroxymethylcytosine, or 5-hmC is a modified form of 5-mC. It has been shown that 5-hmC and the broadly studied 5-mC cannot be distinguished by sodium bisulfite conversion.

Bisulfite Conversion

Bisulfite Conversion is the use of sodium bisulfite to convert cytosine residues to uracil, but leaving 5-methylcytosine residues unaffected. This allows analysis of DNA methylation patterns.

Bisulfite DNA Amplification

Bisulfite Conversion allows analysis of DNA methylation patterns. After conversion, amplification of treated DNA is the first step in many methylation analysis protocols.

CpG Island Microarrays

CpG Island Microarrays use probes to short fragments designed to cover CpG Islands throughout the genome for genome-wide measurement of DNA methylation changes.

DNA Methylase Enzymes

DNA Methylases are enzymes that will methylate DNA at certain residues. These can be used create control samples, and/or to help assess the accuracy of a DNA methylation assay

DNA Methylation Control DNA

Methylated DNA can be used as a useful control in DNA methylation analysis experiments.

DNA Methylation Dependent Restriction Enzymes

Methylation Dependent Restriction Enzymes cleave DNA at specific methylated-cytosine residues in CpG motifs which have a methyl group, leaving unmethylated DNA intact.

DNA Methylation Enrichment Kits

DNA Methylation Enrichment Kits are are optimized systems that bind to methylated DNA. The most common use antibodies (MeDIP) or methyl binding proteins (MBPs).

DNA Methylation Sensitive Restriction Enzymes

Methylation Sensitive Restriction Enzymes cleave DNA at specific methylated-cytosine residues in CpG motifs which have lost their methyl group, leaving only hypermethylated DNA intact.

DNA Methylation Sequence Enrichment

Unlike DNA Methylation Enrichment Kits, DNA Methylation Sequence Enrichment products enable sequence-specific enrichment of genomic regions for targeted DNA methylation studies. These systems are useful for taking deeper looks into targeted regions.

DNA Methylation Sequencing and Pyrosequencing Reagents

After bisulfite conversion and amplification of samples, sequencing of targeted genomic regions can be used to analyze the methylation patterns within that region.

DNA Methylation Sequencing Services

DNA Methylation Sequencing Services harnesses the power of advanced sequencing techniques to identify the sequences of methylated genomic regions within a given sample.

DNA Methylation Specific PCR

Methylation Specific PCR (MSP) analysis uses bisulfite-treated DNA but avoids the need to sequence the area of interest.

DNA Methylation Specific qPCR

Methylation Specific qPCR is based on Methylation Specific PCR (MSP), but provides a quantitative analysis using real-time PCR.

DNA Methyltransferase Enzymes and Assays

Methyltransferase enzymes can be used to methylate sample DNA, or be used to study mechanisms of DNA methylation.

DNA Methyltransferase Kits and Assays

DNA-Protein Binding Assay Kit

Epigenetic Research Instruments

Epigenetic Research Instruments are devices that automate or simplify epigenetic techniques and protocols.

Global DNA Methylation Detection

Global DNA Methylation Detection provides a method to measure global DNA methylation shifts.

HRM DNA Methylation PCR

High resolution melting analysis(HRM)is a real-time PCR-based technique to differentiate converted from unconverted bisulfite-treated DNA to asses DNA methylation

MALDI-TOF DNA Methylation Analysis

MALDI-TOF takes advantage of Mass Spectrometry and Bisulfite Conversions to determine the specific pattern of DNA methylation of CpG sites.

Methylight Assays

Real-Time Methylation PCR-Methylight assays are used to analyze DNA methylation. MethyLight Assays enable discrimination between unmethylated and methylated sites in the same sample.

MSRE Based DNA Methylation qPCR

MSRE based DNA Methylation qPCR uses restriction enzymes (MSREs)to digest DNA at specific sites according to methylation status, which can then be measured by qPCR.

Nuclear and Cellular Extraction Kits

Whole Genome Amplification

Whole genome amplification (WGA) is a group of procedures that allow amplification to occur at many locations in an unknown genome.

ChIP Kits and Reagents

Chromatin immunoprecipitation (ChIP) is a tool for identifying proteins, including histone and non-histone proteins, associated with specific regions of the genome by using antibodies.

ChIP PCR Kits

Chromatin Immunoprecipitation (ChIP) PCR Assays are PCR primer sets or arrays designed to measure genomic DNA enrichment among ChIP-purified DNA samples.

ChIP-Chip and ChIP-Seq Services

ChIP-chip & ChIP-seq combine chromatin IP with microarray or sequencing to investigate interactions between proteins and DNA in vivo. These experiments can be run for you as a service.

ChIP-Chip Microarrays

ChIP-chip is a technique that combines chromatin immunoprecipitation with microarray technology. Like regular ChIP, ChIP-on-chip is used to investigate interactions between proteins and DNA in vivo.

Epigenetic Research Instruments

Epigenetic Research Instruments are devices that automate or simplify epigenetic techniques and protocols.

Histone Acetylation Kits and Assays

Histone acetyltransferases (HAT) are enzymes that acetylate lysine amino acids on histone proteins and play a crucial role in transcription, differentiation, and proliferation.

Histone Deacetylase

Assays to measure and detect to activity of histone deacytlase enzymes (HDAC)

Histone Demethylase Kits and Assays

Histone Methylation Kits and Assays

Histone Methyltransferase Kits and Assays

HIstone Peptide Antibodies

Histone Peptide Arrays

Histone Peptide Arrays provide a tool to screen antibodies, enzymes and proteins for cross-reactivity or binding interactions with histones and their modifications.

Histone Phosphorylation Kits and Assays

Histone Quantification Kits and Assays

Histones

Recombinant histones used to study function of histones and their variants.

Nuclear and Cellular Extraction Kits

Protein Arginine Methylation

Protein Arginine Methylation is a form of epigenetic regulation that effects gene expression via post-translational modifications and the placement of methyl marks on histones and other proteins.

Sumoylation Kits and Assays

Tiling Microarrays

Tiling arrays use short fragments designed to cover the entire genome or areas of the genome in gene expression analysis, transcriptome mapping, ChIP-chip, MeDIP-chip,DNase Chip studies and array CGH.

Epigenetic Research Instruments

Epigenetic Research Instruments are devices that automate or simplify epigenetic techniques and protocols.

Exosome Isolation Kits

Exosome Isolation Kits enable the collection and processing of exosomes for analysis.

miRNA Analysis Services

miRNA Analysis Services allow you to take advantage of the expertise companies have developed in the miRNA field to profile miRNA expression in your samples.

miRNA Cloning

miRNA Cloning Kits are used for cloning and identifying miRNAs within a cell or tissue.

miRNA Inhibition

miRNA Inhibition techniques are used in functional miRNA studies to assess miRNA regulation after it has been inhibited in a model system.

miRNA Linear Amplification

miRNA linear amplification approaches increase the overall target representation of miRNAs in a given sample.

miRNA Microarray Labeling

miRNA Microarray Labeling kits enable you to add fluorescence to the end of miRNAs, or other small RNAs, in your sample so that you can profile their relative abundance by microarray.

miRNA Microarrays

miRNA Microarrays allow a researcher to profile the expression of virtually every miRNA in a sample simultaneously on one array slide.

miRNA Over- Expression

miRNA Over-Expression techniques are used in functional miRNA studies to assess miRNA regulation after it has been introduced into a model system.

miRNA Purification and Enrichment

miRNA Purification kits make sure you’ll keep the small RNA species in your sample from hitting the waste bin.

miRNA qRT-PCR

miRNA qRT-PCR uses the same techniques as normal qRT-PCR with just a few tweaks to allow the detection, quantification and profiling of miRNAs in your sample in a highly specific way