Timeline for DNA Methylation in Mouse DevelopmentApril 4, 2012Not everyone is onboard with the new Facebook timeline, but here’s a timeline you can really get into. Researchers are reporting the first genome-scale, base-resolution timeline of DNA methylation in the mouse embryo, including an analysis of the DNA methylation of oocytes and sperm. To do this, the team analyzed mouse oocytes, sperm, zygotes, early […]
Webinar: Uncover Epigenetic Signatures Faster using SureSelectXT Human Methyl-SeqApril 3, 2012Agilent Technologies presented a Webinar back in March titled: Uncover Epigenetic Signatures Faster using SureSelectXT Human Methyl-Seq SureSelect is the most complete, flexible and proven Target Enrichment platform for Next Generation Sequencing. This presentation highlights features of the new SureSelect SureSelectXT Human Methyl-Seq kit including: • Reduced bias compared to existing Methylation methods • Comprehensive […]
Webinar: Global and Locus-Specific 5-hmC DetectionMarch 21, 2012New England Biolabs is hosting a free webinar titled: Global and locus specific 5-hydroxymethylcytosine detection and quantification Tues. March, 27th 2012 at 9am PDT It will discuss simple and quick enzymatic methods for global, as well as sequence-specific, determination of both DNA modifications throughout various genomes. T4 phage B-glucosyltransferase has emerged as the enzyme of […]
Nutritional Epigenetics: Eating For Two (Generations)March 20, 2012A new study on pigs (used as models for humans) suggests that what you eat could affect your grandchildren much later on. Pigs who ate a special “methyl” diet had “grandpigs” with different DNA methylation and gene expression patterns than the DNA methylation patterns in the control group. Sure, the findings could help researchers build […]
BrdU Kicks Out DNA Methylation and Kicks Off Stem Cell DifferentiationMarch 7, 2012For many things in life, convenience comes at a cost. Like living in a great city with everything at your doorstep, but the rents are sky-high. A new report says that the use of BrdU, a popular tool for detecting replicating cells (such as neural stem cells in the brain), also comes with a cost, […]
3.7M CpGs Await with Improved Methyl-Seq Target EnrichmentMarch 3, 2012March 3, 2012 Instead of sequencing (and paying for, managing, storing, and analyzing) everything, target enrichment blazes through samples like a combine, harvesting for regions of interest. Even as sequencing costs drop towards that “$1,000 genome” level, enriching for select targets makes a lot of sense, especially if you only want to look at a […]
Epigenetics at the Intersection of Environment and SelectionFebruary 28, 2012One of the most fascinating things about epigenetics is the implication it has for inheritance and evolution. Theories and hypotheses are everywhere, of course, but until Sir Richard Branson launches a Virgin Time Travel business, actually measuring the changes from thousands of years of natural selection will remain a pretty tall order. Two recent papers […]
The New Human Epigenome Browser from WashUFebruary 23, 2012Looking for the latest in epigenome data analysis tools? Then you’ll want to check out Washington University’s latest creation; The Human Epigenome Browser. Built as part of the Roadmap Epigenomics Project to house and view Human Epigenome Atlas data, this new platform comes with all sorts of slick features to make analyzing, comparing and integrating […]
Emerging Details On Monoallelic Silencing in TumorsFebruary 19, 2012It’s funny how research can pay off in surprising ways. In this case, University of Wisconsin scientists were studying the tumor suppressor gene APC when they realized there was an unusual brand of monoallelic silencing going on. Earlier studies have found that many early adenomas begin with the loss of function of the Adenomatous polyposis […]
Epigenetics and TwinsFebruary 8, 2012Every summer outside Cleveland, Ohio identical twins congregate at the Twins Days Festival. Twins from all over join in on an assortment of activities over three days that resembles a massive Doublemint® gum commercial. It’s not just the twins that get stoked for the festival though. As was highlighted in a nice article in National […]
