Redefining DNA Methylation in Cancer with Dr. Andrew FeinbergAugust 1, 2012Dr. Andrew Feinberg discusses how recent events are reshaping the way his team thinks about DNA methylation in cancer. This interview was shot on campus at Johns Hopkins University. This video was brought to you by epigenetics supporters at EMD Millipore. Redefining DNA Methylation in Cancer Well, there are a number of things I’m […]
Pol II Transcription Slows at 5-Formylcytosines (5caC) and 5-Carboxylcytosines (5fC)July 31, 2012It’s summertime—a time when you just want to take things slow. Researchers now report that 5-formylcytosines (5fCs) and 5-carboxylcytosines (5caCs) like to slow things down, no matter what the season. They say that these mods put the brakes on RNA Pol II transcription and make it less specific. Sure, researchers have known about 5fC and […]
Exploring the Genotype-Chromatin Structure-Disease Risk ConnectionJuly 26, 2012Its easy to obsess over little details, and want to understand every nuance of a subject that you’re passionate about, but sometimes it’s helpful to step back and get a broader perspective on what you’re working on. This review article from Richard Meagher and Kristofer Müssar at the University of Georgia does just that by […]
More Epigenomic Differences Found in Twins?July 24, 2012Twins may look alike, and even share identical genomes, but according to new studies, their epigenomes can be surprisingly different. Examination of the DNA methylation patterns in sets of twins revealed that early environmental conditions can alter epigenomes, and have a big impact on individual variability. A research effort headed up by Jeff Craig and […]
Pushing the Technology Frontier in Epigenetics Research with Dr. Andrew FeinbergJuly 16, 2012Dr. Andy Feinberg discusses what technology advances are needed in the field of epigenetics. This interview was shot on campus at Johns Hopkins University. This video was brought to you by epigenetics supporters at EMD Millipore Single Cell Analysis One of the areas I think is going to be really important is single-cell analysis. […]
Guide: Simple Tips to Boost Your Bisulfite-Based ApplicationsJuly 11, 2012 Bisulfite conversion remains a key player in almost every study involving DNA methylation. Since DNA methylation is emerging as a key mechanism in a diverse range regulator processes and disease mechanisms, many researchers new to the field are turning to bisulfite-based analyses that might not be experts in the approach. We’ve been optimizing bisulfite […]
Step Up Your Bisulfite: DNA Methylation Analysis Tips for Challenging SamplesJuly 11, 2012Sooner or later researchers studying DNA methylation turn it up a notch and get into some difficult sample scenarios, where the interesting data hides tucked away. We caught up with the R&D scientists at Zymo Research to hear more about some of the challenges that researchers face when stepping up into some of these sample […]
Wrapping Your Mind Around Brain DNA MethylomesJune 28, 2012Not much is known about the normal DNA methylation differences between functionally different parts of the brain or how they relate to the patterns in peripheral tissues like blood. In a new study, scientists extensively mapped out the brain methylome to create a baseline resource for use in future research efforts. Researchers from King’s College […]
DNMTs Determine Radiation Sensitivity of Cancer Stem CellsJune 27, 2012Radiation therapy usually works well against cancer, but some cells that survive the blast can divide and become unstable (cancerous) much later on, causing a relapse. Researchers initially thought that DNA hypomethylation was to blame for “delayed radiation-induced genomic instability,” but a new study in Epigenetics, August 2012 shows that, at least for embryonic stem […]
NIH Roadmap Epigenomics Program Data ResourceJune 18, 2012Last August, we shared with you some of the great new online resources being developed by the NIH Roadmap Epigenomics Program. Now, the latest issue of Epigenomics, has published an update of all the latest editions, tweaks and refinements they’ve made over the last year. The NIH Roadmap Reference Epigenome Mapping Consortium has created a […]
