CRISPR-Cas, Zinc Fingers and Epigenetic Editing with Dr. Marianne RotsFebruary 27, 2014Epigenetic Editing is an emerging field that has sparked interest across a number of research groups. By using a fusion of TET we can now target specific genomic regions for demethylation in order to learn about their function and regulation. We got in touch with one of the field’s experts, Dr. Marianne Rots, commissioning editor of Clinical Epigenetics, […]
Cells Take Epigenetic Cues from Tissue Environment, TooFebruary 19, 2014A ton of time and effort has been spent recently to detail how the external environment can shape our epigenome, but now Peter Jones and company at USC show that we shouldn’t underestimate the power of our internal environment. In a new published report, the USC team found that the extracellular cues taken from the surrounding tissue […]
DNA Methylation Detection In the Palm of Your HandFebruary 19, 2014Thanks to our never-ending obsession with miniaturizing technology and competitions like the Tricorder X-prize, it looks like everyone’s favorite piece of Star Trek medical paraphernalia, the Tricorder, may be just around the corner. A team from the University of Queensland has developed a new micro-device that creates a simple, rapid, and inexpensive strategy for detecting DNA […]
NOMe-Seq Secrets RevealedFebruary 17, 2014You’ve read the NOMe-seq (Nucleosome Occupancy and Methylome sequencing) papers. Seen the splashy advertisements. Now, we’ve consulted with the experts at Active Motif to get the inside scoop on how to get started, and get the most out of your NOMe-seq experience. NOMe-Seq was originally published and developed by researchers in the Peter Jones lab […]
Environmental Epigenetics TimelineFebruary 11, 2014Thanks to growing interest from the general public, environmental epigenetics is a red-hot topic with no signs of cooling off anytime soon. We’ve certainly covered our fair share of research with an environmental slant to it, so if you want to review, research, or just plain get up to speed on the subject, these articles […]
Clinical Epigenetics TimelineFebruary 10, 2014The underlying goal for most epigenetic research projects is to eventually lead to a therapeutic clinical application. Here we provide a history of clinical epigenetic advances in this interdisciplinary field as told through our articles and Conference Highlights.
Epigenetics of Cancer TimelineFebruary 9, 2014Epigenetic mechanisms have been studied in cancer for decades. Unfortunately, we haven’t been around that long, but check out these great articles that capture the recent history of epigenetic breakthroughs in cancer.
Evolution of Advanced Sequencing TimelineFebruary 7, 2014In a few short years. advanced sequencing has become nearly ubiquitous. Here we provide a history of how emerging sequencing technologies have driven epigenetic research and understanding.
The New Players in Epigenetic Reprogramming with Dr. Wolf ReikFebruary 3, 2014Dr. Wolf Reik discusses the latest advances in epigenetic reprogramming, and what those new discoveries might lead to. The New DNA Methylation Landscape So it’s become apparent in the last two years, I guess, that there is this process of genome-wide epigenetic reprogramming which occurs naturally in germ cells, early embryo stem cells, et cetera, […]
Webinar: Mechanisms of Epigenetic Regulation in Stem Cells and DevelopmentJanuary 31, 2014Dr. Alexander Meissner discusses the roles of epigenetic mechanisms in stem cells and development. Cytosine methylation in mammals is an epigenetic modification that is largely restricted to CpG dinucleotides and serves multiple critical functions including stable repression of target promoters, maintaining genomic integrity, establishing parent-specific imprinting patterns, and silencing endogenous retrotransposon activity. In somatic tissues, […]
