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EpiGenie Features call out new Methods, provide Insights into emerging trends, or sometimes just share technical tips from the experts in our community.

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Epigenetics: Getting to Know the Readers and the Writers with Dr. Jerry Workman

May 31, 2013

Dr. Jerry Workman shares some of his thoughts on the next steps in digging into biochemistry of epigenetic mechanisms to understand what’s reading and what’s writing. Epigenetics: Getting to Know the Readers and the Writers I think the most exciting aspect about epigenetics at this time is the potential it provides for some fantastic […]

Free Protocol Guides: RIP and iCLIP

May 23, 2013

So you’ve been following RIP and CLIP over the last couple of years and you’ve seen what researchers can do with these methods. Now it’s time to roll up the sleeves and put the pipette in action. The kinds folks over at Abcam have some nice protocol guides to help you get fastracked to RIP […]

Epigenetics in Stem Cells Timeline

May 7, 2013

Epigenetics and stem cells go hand in pipette. These two research areas have seen explosive growth so we thought we’d highlight some of our favorite highlights.

The Future of lncRNAs with Dr. John Rinn

May 2, 2013

Dr. John L. Rinn from Harvard University and the Broad Institute (Harvard and MIT) is a prominent researcher in long non-coding RNAs (lncRNAs) and agreed to sit down and discuss his perspective on the intersection of lncRNA and epigenetics. EpiGenie: You’ve mentioned that you feel knockout models are going to play a key role in the […]

Looking Under the Hood of Gene Regulation with Dr. Steven Henikoff

April 24, 2013

Dr. Henikoff discusses the next phase in gene regulation research, establishing causality in the gene expression flow and who the key players are. Looking Under the Hood of Gene Regulation The field in general I think has changed,so in just a few years, I think what we’ve seen is that there is much more gettingdown to nitty gritty, what’s underneath the hood, as opposed to the chrome on the top. And that comes through when we begin to understand what the relationship is between starting from a transcription factor causing expressionof a gene, basically causing RNA polymerase to move and what’s the interaction between RNA polymerase and nucleosomes, how that leads to histone modifications, how the histone modifications can help stabilize, for example, the nucleosomes. So these are the questions that we’re sort of beating around the bush and about a couple of years ago, but now I think we’re beginning to understand how it all happens and what the chain of causality is, for example. And also, not just withthe players are but what the interactions are and how it actually works dynamically. So we’d like to think of chromatin in […]

Epigenetic Mechanisms in Autism

April 24, 2013

Autism spectrum disorder (ASD) refers to related neurodevelopmental disorders characterized by deficits in reciprocal communication and social interactions, coupled with restricted and repetitive patterns of behavior, interests and activities. Because ASD tends to run in families, much effort has been spent on genetic analyses to identify genetic variations that either cause or elevate risk for […]

Guide: Getting Started with Genome-Wide 5-mC and 5-hmC Sequencing

April 10, 2013

With recent advances in sample preparation, highthroughput sequencing, and bioinformatics, researchers looking to study DNA methylation and hydroxymethylation now have several options for investigating these epigenetic modifications on a genome-wide scale. The following technologies offer varying levels of resolving power, with some offering regional estimates of DNA methylation status, while others provide quantitative values at […]

Investigating Long Distance Chromatin Interactions with Dr. Gerd Blobel

April 4, 2013

Dr. Gerd Blobel discusses chromatin organization and the recent technology developments that have deepened our understanding of regulatory domains in the nucleus. Investigating Long Distance Chromatin Interactions So there have been phenomenal developments in our field which address the mechanism of chromatin organization. And I would argue that it’s like in the early days […]

Chromatin Modifications in Enhancers

March 20, 2013

Enhancers serve as distal regulators of gene expression, but insights into the precise mechanisms of enhancer chromatin modifications are still lacking. In this recent review, Calo and Wysocka summarized various enhancer-associated modifications and propose how these modifications regulate enhancer activity during development. Here are some of the key topics discussed: The Enhancer Chromatin Landscape Enhancers […]

The 3D Genome: A Review into Genomic Organization and its Key Players

March 20, 2013

Our genome is not linear. Nope, it’s a three-dimensional labyrinth of regulatory nooks and crannies . Gibcus and Dekker recently published this free review that looks at the spatial hierarchy of genomic organization and how it modulates gene expression. This is a great resource for those of you looking to beef up your understanding of […]

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