Features

Features

EpiGenie Features call out new Methods, provide Insights into emerging trends, or sometimes just share technical tips from the experts in our community.

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The Embryonic Journey of DNA Methylation Dynamics

August 5, 2014

Two recent Nature papers made big strides in understanding mammalian embryonic DNA methylation. The Meissner and Eggan team from Harvard focused in on CpG dynamics and how they compare to mice, specifically in terms of parental contribution. While the Qian and Tang team from Bejing examined how DNAm effects the epigenetic embryonic landscape in terms of histone […]

Webinar: Using CRISPR/Cas9 Technology for Editing Genes in Haematopoietic Cells and Mice

July 29, 2014

Presented by: Dr Marco Herold, Laboratory Head, Molecular Genetics of Cancer Division, The Walter & Eliza Hall Institute of Medical Research Abstract: The CRISPR/Cas9 technology provides an easy and rapid way to edit genes in vitro and in vivo. Initial experimental strategies utilized a transient transfection approach to modulate genes in vitro, but this proved […]

Webinar – Bringing ChIP Seq Data into Focus: Advanced Normalization Strategies

July 23, 2014

If you’ve ever struggled to make sense of your ChIP Seq data, then check out this webinar presented by our colleagues at Active Motif, to get some ideas on how to bring some order to the chaos of ChIP-seq. Presented by Brian Egan, Ph.D, Epigenetic Services Manager at Active Motif Normalization of ChIP-seq Data Today, […]

5′ UTR miRNA Targeting

July 21, 2014

The nightly news lately makes it seem like the world has gone upside down, and now we’ve got some science to back it. Honglei Zhou and Isidore Rigoutsos from Thomas Jefferson University recently revealed that mammalian miRNA targeting doesn’t always limit itself to 3′ miRNA action. It now seems that in addition to the traditional 3’UTR […]

Going Global with DNA Methylation Analysis

June 24, 2014

It’s human nature to get enthralled by the latest, shiny new technology on the market, but sometimes a more established approach is just as effective. We recently connected with our friends at Zymo Research who point out that for DNA methylation analysis, researchers may not always need all of NGS’s bells and whistles, especially when […]

Kit Competition Reveals Hacks to Help Bisulfite Conversion

April 16, 2014

At first pass it may seem like all bisulfite conversion kits are essentially the same – and for the most part, that’s true. But according to a recently published evaluation, the conversion is all in the details, and if those are overlooked it can have a big impact on the results. Fortunately, researchers from the […]

Transgenerational Epigenetic Inheritance Timeline

March 17, 2014

Molecular inheritance is what genetics is all about, so here we highlight some examples where the epigenome plays a key role in inheritance.

EpiGenie Book Reviews: Epigenetics by L. Armstrong

March 14, 2014

After working on some of the UK’s first embryonic stem cells and developing the world’s first cloned human embryos, Lyle Armstrong turned his attention to the creation of a useful text that would benefit the epigenetic novice as well as the seasoned investigator. With a number of groovy figures and illustrations, they key concepts of […]

Webinar: Genetic Analysis of the Physiological Roles for lncRNAs in Development

March 8, 2014

Loyal A. Goff, Ph.D presents his research on: Genetic Analysis of the Physiological Roles for lncRNAs in Development Abstract: Many studies are uncovering functional roles for long noncoding RNAs (lncRNAs), yet few have been tested for in vivo relevance through genetic ablation in animal models. To investigate the functional relevance of lncRNAs in various physiological […]

CRISPR-Cas, Zinc Fingers and Epigenetic Editing with Dr. Marianne Rots

February 27, 2014

Epigenetic Editing is an emerging field that has sparked interest across a number of research groups. By using a fusion of TET we can now target specific genomic regions for demethylation in order to learn about their function and regulation. We got in touch with one of the field’s experts, Dr. Marianne Rots, commissioning editor of Clinical Epigenetics, […]

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