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Features

EpiGenie Features call out new Methods, provide Insights into emerging trends, or sometimes just share technical tips from the experts in our community.

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CpGT and MethylGPT – Large AI Models Lay the Foundation for Advanced DNA Methylation Analysis

November 27, 2024

Vast amounts of DNA methylation data have paved the way for epigenetic clocks to significantly advance aging research; however, generative artificial intelligence (AI) may have now laid the foundation for more transformative insights into DNA methylation. Two preprints report the application of transformer architecture to develop “foundation” or large AI models trained on vast DNA […]

eBook: DNA Methylation 2024

May 15, 2024

DNA methylation, whether in cells or in a cell-free environment, is one of the most powerful and most studied epigenetic regulators of gene expression and genomic organization. This is true for nearly all organisms, leading to the emergence of numerous methods for mapping 5-mC and 5-hmC and other modification states. There are many approaches for […]

eBook: New & Novel Methods for Epigenetic Analysis

February 7, 2024

Epigenetics is not new, but methods used for analysis certainly can be! In this eBook, we take a look at, and present in a simple format, some of the hottest new methods for researchers looking at DNA Methylation, RNA modifications, Chromatin and Gene Regulation. Topics Include: Differential Methylation Data Are Quick, Easy, and Inexpensive with […]

uCoTarget Is a Single-Cell Multiomics Method for Multiple Histone Modifications

January 17, 2024

Everyone loves a bargain, and a new method called CoTarget really delivers. It’s a method that delivers single-cell multiomics data on multiple histone modifications and transcription factors, as well as the transcriptome. It can easily scale up to analyze a million single cells, and unlike similar methods, it doesn’t require microfluidic devices or special transposon […]

The Brain Cell Census: A Deeper Epigenomic Understanding of the Mammalian Mainframe

November 13, 2023

If you have epigenetics on the brain like us, concentrate your mammalian mainframe on the recently published marvels on the brain’s epigenome from the NIH’s Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative – Cell Census Network (BICCN). Recent work brought together under the guise of the Brain Cell Census now reports on the examination […]

Kacme: A New Histone Modification Couples Methylation and Acetylation to Mark Active Transcription

October 23, 2023

Some couples seem unlikely, yet somehow, they work (a recent pop star-football player pair comes to mind). Now, an even more surprising couple—a methyl group and an acetyl group—hanging out together on the very same lysine residues on histone H4s has just been spotted across species and appears to be involved in active transcription. Mind. […]

eBook: RNA & Transcriptomics

October 13, 2023

Analysis of the working of our RNA, from transcription and splicing to translation, began in a simpler time – when we talked about “RNA” and hadn’t yet recognized the whole range of RNA species, including miRNAs, ncRNAs, and more. These days, we are learning as much about the epigenetic modification of RNA and the role […]

Epigenetic Inheritance During DNA Replication: A State Lying Somewhere Between Symmetry and Instability

October 2, 2023

Emerging research has provided evidence for the critical importance of the inheritance of epigenetic states, whether that be DNA methylation, histone modifications, or even non-coding RNAs. Now, three recent studies focusing on the mechanism involved in passing down this information from parental to daughter cells while they replicate their DNA and divide in vitro provide […]

Just Add HiDRO to Figure Out How Genomes Fold in Single Cells

September 14, 2023

Water hydrates and is essential for life—for plants, humans, and even fish. So, it’s fitting that a new technique called HiDRO takes high-throughput FISH to the next level to identify factors that help genomes fold in 3D at high throughput in single cells. Cohesin helps DNA form loops, which can then form topologically associated domains (TADs). […]

An Evolutionary and Epigenetic Tour-de-force Links DNA Methylation and Mammalian Aging

September 11, 2023

Have you climbed Mount Everest? Recorded a critically acclaimed album?? Written the great American novel??? These life-affirming feats of body and mind pale into insignificance when compared to the evolutionary and epigenetic tour-de-force reported in two recent papers based on mammalian DNA methylation datasets of colossal size and importance. An expeditionary force led by Steve […]

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