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Features

EpiGenie Features call out new Methods, provide Insights into emerging trends, or sometimes just share technical tips from the experts in our community.

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Epigenetics: Damage Control in the Cell with Dr. Jim Haber

July 25, 2013

Dr. Haber discusses how normal cells deal with DNA damage and genomic integrity; and how those systems go awry in cancer cells. Epigenetics: Damage Control in the Cell Well, I work in an area of DNA repair. And what we have come to realize over the last decade is how these repair mechanisms prevent cells […]

The Dynamic Epigenome

July 24, 2013

EpiGenie recently reviewed the text Epigenetics by Jorg Tost. Here is a more in depth summary of one the chapters provided courtesy of JA Gill who is molecular biologist at NOAA in the Northwest Fisheries Science Center, to give you a little sneak peek into what the whole book is all about: The Dynamic Epigenome: […]

EpiGenie Guide: RNA Immunoprecipitation (RIP) and Beyond

July 10, 2013

RNA binding proteins (RBPs) play important roles in many cellular and disease processes, together with their DNA binding brethren, they compromise almost one quarter of annotated human genes. The tools used to understand when and where these proteins bind and interact with RNAs in the cell have lagged behind those for protein-DNA interactions, although they […]

The Darkside of Epigenetic Plasticity

June 26, 2013

Sure, genes get mutated in cancers, but the epigenome gets messed-up too. In fact, two researchers argue in a recent review that a “dysregulated epigenome” that’s too plastic and flexible could itself lead to cancer. Andrew Feinberg and Winston Timp, both from the Center for Epigenetics at the Johns Hopkins School of Medicine, wrote the […]

Webinar: Lighting up the Dark Matter of the Genome – Unravelling the Roles of Non-Coding DNA in Disease and Development

June 26, 2013

Dr. Marcel Dinger, PhD discusses some of the most recent findings that shed light on non-coding RNAs in the genome. **this webinar is no longer available** Abstract Approximately 98% of the human genome comprises noncoding DNA, the function of which is largely unknown. Intriguingly, more than 85% of single nucleotide polymorphisms identified to be associated […]

Keeping Up with Live Cell DNA Looping

June 25, 2013

The reality TV era has made voyeurs of us all. So it makes sense that we’d want to take a peek inside live cells too. Now comes a report of a new method that shows, for the first time, DNA getting loopy inside live E. coli cells. Johns Hopkins University Med School researchers say that […]

DeepSAGE Digs up Expression Differences in 3’ Ends

June 24, 2013

It isn’t always a good thing to get the end of something, but researchers say that by grabbing onto 3’ ends of transcripts and tagging them, DeepSAGE digs deep, getting low-level transcripts and getting new info on their “back-ends.” That could be important for figuring out exactly how gene expression changes with disease. “It was […]

HDAC-Glo™ Brightens up HDAC Activity Screening

June 21, 2013

Histone Deactylase (HDAC) researchers have been clamoring for more sensitive and reliable HDAC assays in order to generate the high quality data that previous techniques don’t always deliver. The HDAC-Glo™ I/II Assays and Screening Systems from Promega aim to shine new light on the matter with highly sensitive assays that ditch the old, troublesome false […]

Application Note: Automated Bisulfite Conversion

June 14, 2013

Unlike more mainstream assays, bisulfite conversion approaches have been dependent on manual manipulation of spin plates and columns or have been of limited throughput. By adapting the clean-up of bisulfite converted DNA to a magnetic bead based procedure and coupling it to the Freedom EVO® platform, Zymo Research has opened the door to high-throughput bisulfite […]

Free Short Course: Epigenetic Control of Gene Expression

June 7, 2013

If you’re new to the field or just want to brush up on an aspect of epigenetics that you don’t follow that often, Dr. Marnie Blewitt from the University of Melbourne, Australia is hooking you up with a free, six-week crash course. This course will cover the principles of epigenetic control of gene expression, how epigenetic control […]

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