Features

Features

EpiGenie Features call out new Methods, provide Insights into emerging trends, or sometimes just share technical tips from the experts in our community.

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Bulletproof Your Bisulfite Conversion: Key Considerations from the Experts

December 1, 2009

There’s a lot of talk out there about bisulfite conversion, how useful it is, how it’s the “Gold Standard,” how laborious it is, how rough it is on your samples, but the reality of it is that there probably isn’t any better way to prep your samples for single nucleotide resolution methylation profiling, so don’t […]

Sopping Up Regulatory Insights with miRNA Sponges

November 17, 2009

We’ve all seen those household cleaning commercials on the tele that show a super detergent that cuts through grease, whitens whites, and zaps pet odor effortlessly, so when we first got wind of miRNA sponges a few years back (Nature Methods, August 2007), we remember being interested but skeptical. But, if these vector-driven miRNA inhibitors […]

MBD-Sequencing: The Latest Methylation Analysis Cocktail Delivers

November 17, 2009

Add 1 part enriched methylated DNA to 2 parts sequencing lanes, and you have a cocktail that delivers key insights without a data hangover. Last week, a team of Ohio scientists added the latest research recipe that is destined to become a lab fav in Nucleic Acids Research. The crew took the benefits of methylation […]

The Dark-side of Being a Regulatory Star: miRNA Labeling and Manipulation

November 11, 2009

It wasn’t that long ago when cellular miRNAs lived under the radar. They went to work on their targets each day and hung out with other members of the extended RISC family. Their small size and lack of poly-A tails may have kept them out of the spotlight for decades, but the last few years […]

Epigenetic Drugs: More Than Hype in the Pipeline

November 5, 2009

It’s 10 p.m. on a Friday night, and you’re still stuck in the lab doing ChIP assays. As the piercing whine of the sonicator frays your last nerve, you ask yourself again, “Why did I go into epigenetics research…why couldn’t I have chosen something simpler and more straightforward (like rocket science)?” At times like these, […]

miRNA Target Prediction Program Round-up

October 21, 2009

As miRNA discovery continues to skyrocket, the obvious question is: What are these miRNAs targeting? Lately, that topic seems to be as hot as any “Jon & Kate Plus 8” gossip. Several programs have been created to get at that question, and predict targets for miRNAs, but it’s hard to know which ones are really […]

Dr. Adrian Bird: Interview With A Pioneer in Methylated DNA

October 21, 2009

One of the things we enjoy most at EpiGenie is chatting with the researchers who are driving epigenetics forward. So, naturally we were stoked to come across an interview with Dr. Adrian Bird in PLoS Genetics. Adrian Bird is the Buchanan Chair of Genetics at the University of Edinburgh and is also Director of the […]

Non-Coding (RNA) Doesn’t Have to Mean Non-Sense

October 14, 2009

Our understanding of non-coding RNAs has ramped up like a quarter pipe at the X Games over the last several years and, if recent publications are any indication, we’ve only scratched the surface. The realization that just a sliver of our vast transcriptomes is protein-coding, much of it is churned out in both directions, and […]

The First Completed DNA Methylomes Cover All the Bases

October 14, 2009

Halfway into October, we’re deep into post-season baseball. Although, the Padres haven’t given us local San Diegans much to boast about this year (or last), local standouts at the Salk Institute and UCSD knocked one out of the park this week in Nature. Here’s a team that really knows how to cover the bases, all […]

ChIP-Seq Analysis: May All Sequences Be Treated Equal

October 14, 2009

“All men are created equal” is one of the most famous phrases in U.S. politics, but it took a while for this concept to be adopted by researchers dealing with repetitive sequences during ChIP-Seq analysis. The short length of individual deep sequencing reads creates some sequence runs that don’t map to a unique loci on […]

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