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Features

EpiGenie Features call out new Methods, provide Insights into emerging trends, or sometimes just share technical tips from the experts in our community.

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Histone Demethylases Have a “Sixth Sense” about Oxygen Levels!

April 7, 2019

Many people make dubious claims of being endowed with more than the five traditionally recognized senses; their “sixth sense” providing the extrasensory perception needed to converse with spirits and ghosts and predict the future, among other fanciful claims. While there is a lack of any evidence for extrasensory powers and paranormal activity, robust studies have […]

Go CRISPR-Go Go, This Genome Organization Study B. Good!

October 18, 2018

There aren’t many studies exciting enough to make you jump out your lab coat and rock’n’roll round the lab like it’s the 50s, but a recently reported new application of CRISPR might just start your toes tapping and your heads nodding. This new article does not originate from “Deep down in Louisiana close to New […]

Drop-by-Drop Cell Fate Control by Transcriptional Condensates

July 22, 2018

Little-by-little, step-by-step, and drop-by-drop, we are beginning to appreciate the vital importance of intracellular liquid-like droplet formation to fundamental mechanisms such as epigenetic inheritance and heterochromatin domain formation. Liquid-like droplets aid these processes by biological “phase-separation” or the selective concentration of some molecules into a small intracellular area and the exclusion of others. Excitingly, two new […]

Cutting Through the Epigenetic Complexities Linking Aging and Tumorigenesis

March 16, 2018

Writing your first grant proposal? Optimizing that tricky Western blot? Programming an old PCR machine? Only a few things are more complex than our current understanding of the epigenetic links between aging and tumorigenesis, but this has not stopped a few valiant labs from doubling down and busting a few paradigms while they are at […]

The Great Unknown of Chromatin Conformation Dynamics

August 7, 2017

Apart from the ever rising and falling measurements of one’s waistline and bank balance, the three-dimensional (3D) chromatin conformation of the mammalian genome is one of the most dynamic and least understood factors in a scientist’s life. Luckily, the development of new high-definition techniques and enhanced computational analyses are helping us to understand how the […]

Genomic Imprinting’s Alternative Choices: H3K27me3 and 5hmC

July 31, 2017

In today’s world, where choices are a plenty, alternative is a fashionable choice. When it comes to genomic imprinting, traditionalists swear by DNA cytosine methylation (5mC); however, sometimes imprinting turns to alternative epigenetic marks. Genomic imprinting is typically driven by 5mC at imprinting control regions (ICRs), where it represses the expression of the marked allele […]

Environmentally Reprogrammed Sperm Epigenetically Transmit Behavior Across Generations

July 11, 2017

Life’s full of experiences that often seem like a coin toss. Should you go the gym or feast on some sushi? While the epigenetic mechanisms behind the outcomes of these two events may seem quite different at first, when considering the epigenetics of sperm, it turns out they’re two-sides of the same coin. Intergenerational Effect […]

“Drop” Everything for the New Liquid Model of Heterochromatin Domain Formation!

June 30, 2017

The field of epigenetics tends to be very “fluid” with new studies and paradigm shifts seemingly the norm! Now two new studies in Nature have described a new liquid model for the formation and function of silent chromatin domains known as heterochromatin. The predominant view of heterochromatin formation and function tells us that repressive epigenetic […]

Reporter of Genomic Methylation Delivers Imprinting and Epigenome Editing Insights

October 3, 2016

Here at EpiGenie we like to think of ourselves as reporters of genomic methylation, but two new studies from the lab of Rudolf Jaenisch at MIT give us a run for our money and demonstrate the utility of their reporter of genomic methylation (RGM). Using RGM, the talented group brings forth a deeper understanding of […]

Watch out Cas9: Cpf1 Hits the Mark in Human Cells and Creates a Mouse Model

June 15, 2016

In the Wild West of CRISPR genome editing, Cas9 has established itself as a wrangler of animal models that takes out any sequence with an sgRNA bounty on its head. But now there’s a new sheriff in town with marksman aim. CRISPR from Prevotella and Francisella 1 (Cpf1) was brought forth by the pioneering lab […]

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