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EpiGenie Features call out new Methods, provide Insights into emerging trends, or sometimes just share technical tips from the experts in our community.

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Methylome Analysis Today: No One is Perfect

May 18, 2011

With everyone focused on their own daily grind, its easy to gloss over some of life’s more philosophical questions like: “Does a falling tree make a sound if no one is there to hear it?” “What is the sound of one hand clapping?” or even “Are my methylome studies really accurate?” In an Epigenomics review […]

RNA Immunoprecipitation Comes Of Age

May 17, 2011

RNA Immunoprecipitation (RIP) is growing up. After suffering through some awkward adolescent years, RIP has evolved from its humble beginnings in a few hardcore labs and is now stepping out shadow of its more famous cousin, Chromatin Immunoprecipitation (ChIP). The more mature RIP has been steadily building its fan base too with curious researchers seeking […]

Probing Placental Epigenetics

May 3, 2011

Ever since Tom Cruise publicly vowed to eat his newborn’s placenta a few years back, the “afterbirth” organ has gotten a bum rap. But recent evidence suggests that in addition to its long-recognized role in supplying oxygen and nutrients to the growing fetus, the placenta also influences fetal development through epigenetic mechanisms. Now a trio […]

DNA Methylation qPCR Remixed

April 5, 2011

qPCR is used daily to validate array and sequencing results, but qPCR approaches have yet to dominate DNA methylation analysis the same way they have with other applications like gene expression analysis or genotyping. Things are a little bit more complicated when it comes to the epigenetic mods, but that hasn’t stopped hungry researchers from […]

Making The ChIP Antibody Grades

March 29, 2011

Back in the 2000’s most researchers spent their post-ChIP analysis looking at a gel or a PCR curve. Now, they spend their analysis time combing through hard drives of sequencing data. A lot has changed in the world of location analysis, but the need for good antibodies remains the same; which is probably why we […]

Epigenetics in Evolution with Dr Eva Jablonka

March 13, 2011

Dr. Eva Jablonka discusses the role of epigenetics in evolutionary biology. This short take was shot during a break at Keystone Symposia’s meeting on Environmental Epigenomics and Disease Susceptibility held in March 2011 in Asheville, North Carolina. Epigenetics in Evolution Well, what I’m doing really is theoretical work, and I’m mainly interested in the evolutionary […]

5-Azacytidine: The Charlie Sheen of DNA Methylation Inhibitors?

March 13, 2011

As we’ve all recently witnessed, some actors have polished public images but are a mess in real life. After reading two recent papers by groups in Los Angeles and Turkey, it sounds like the same could be said of 5-azacytidine (Vidaza®). Mounds of clinical data now show that 5-azacytidine is a good treatment for blood […]

Genome-Wide Methylation Sequencing Hits the Fast Lane

February 11, 2011

Genome-wide DNA methylation sequencing hasn’t been much more than sci-fi reading for most labs. Sure there’ve been some great papers with really slick technologies, but many researchers just don’t have access to them. In many cases, no single lab can handle the complete experimental workflow from sample prep to data management/analysis, requiring collaborations with other […]

Single Cell Methylation Analysis: Brought to You by RMSA

January 30, 2011

As DNA methylation keeps popping up in the discussion of more and more diseases, it’s clear that current analysis techniques can only give us part of the big picture. To help focus on other parts of that picture, a new method has been devised that zooms in on the methylation status of single cells. The […]

Top Epigenetics Technology Features on EpiGenie

January 14, 2011

Want to catch up on some of the latest methods, new technologies, and expert technical tricks? You’re in the right place. Here’s a list of our favorite emerging Technology and Methods articles from the last year or so to really jump-start your 2011. Check ‘em out! DNA Methylation Analysis Methylome Analysis Snapshot February 11, 2010. […]

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