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Features

EpiGenie Features call out new Methods, provide Insights into emerging trends, or sometimes just share technical tips from the experts in our community.

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EpiGenie Book Reviews: Epigenetics

March 11, 2013

If you’ve spent any time browsing the EpiGenie site, then you already know that we find epigenetics pretty interesting. So, of course any book with the title of Epigenetics is going to grab our attention. Epigenetics edited by Jörg Tost, gathers information from several top scientists working in various facets of epigenetics to assemble a […]

Epigenetics OnDemand: Free Presentations for Download

March 11, 2013

Our friends over at Hanson Wade have clued us in to some great free resources that are so nice, we’re officially referring to them as Handsome Wade now. Check out this greatest hits compilation of talks and presentations from industry and academic epigenetic gurus. Each of these can be downloaded, free of charge using the links below. […]

Guide: Peak Calling for ChIP-Seq

February 27, 2013

Chromatin-immunoprecipitation sequencing (ChIP-seq) is the most widely used technique for analyzing Protein:DNA interactions. Very briefly, cells are cross-linked, fragmented and immunoprecipitated with an antibody specific to the target protein; the resulting ChIP DNA fragments are used as the template in a next-generation sequencing library preparation and many millions of short sequence reads are generated for […]

Guide: Getting Started with ChIP-Seq

February 27, 2013

Chromatin-immunoprecipitation (ChIP) followed by sequencing of the immuno-precipitated DNA is a powerful tool for the investigation of Protein:DNA interactions. To perform ChIP-seq, chromatin is isolated from cells or tissues and fragmented. Antibodies against chromatin associated proteins are used to enrich for specific chromatin fragments. The DNA is recovered, sequenced and aligned to a reference genome […]

EpiGenie Reviews: Genomic Imprinting – Methods and Protocols

February 24, 2013

Genomic imprinting, or examining instances where paternal and maternal genomes aren’t represented equally, has kept many brilliant minds busy for decades. It has also established the foundations for emerging field of epigenetics. In the 2012 update of Genomic Imprinting: Methods and Protocols, edited by Nora Engel, experts in the field cover the most up to […]

Tackling Heterogeneity with DNA Methylation

February 12, 2013

Heterogeneity adds value to our culture in numerous ways, but when it comes to analyzing large-scale case/control studies with blood, heterogeneity can be more frustrating than a Rubik’s Cube. Since blood is an easy-to-get, relatively noninvasive specimen, it’s ideal for disease diagnosis and for monitoring the effectiveness of treatments. Scientists have reported that DNA methylation […]

EpiGenie Guide: ChIP Antibody Validation

February 11, 2013

If you can find a ChIP Grade or ChIP Validated antibody, then you’ve got a head start. But there’s no reason to stress if you can’t. Leave that for the data analysis part of your experiments (only kidding). A quick check of the spec sheet of any antibody can reveal lots of useful info. Here […]

EpiGenie Reviews: RNA Interference and Viruses – Current Innovations and Future Trends

February 11, 2013

RNA interference (RNAi) was first discovered in 1998 and has sparked new innovations and novel research tools for biological research ever since. RNAi has the scientific community buzzing because of it’s huge potential to tackle some of our most dreaded viral infectious diseases, like hepatitis C virus (HCV) and human immunodeficiency virus (HIV). But there […]

The Epigenetics of Organ Transplantation

January 31, 2013

Dr. Daniel Salomon discusses the state of organ transplants, what obstacles exist, and how epigenetics might be central to improving long-term health in patients. The Challenges in Transplantation My background is in transplantation medicine, transplantation immunology. And my interests are to change the way we manage patients. There’s a huge series of challenges right […]

Top Epigenetics and Non-Coding RNA Conferences for March

January 23, 2013

Although it’s warm and sunny at EpiGenie’s headquarters, we know that most of the northern hemisphere is counting the days to spring. Researchers hungry for great epigenetics and ncRNA conferences also have a lot to look forward to with an impressive line up of conference options kicking off in March. We’ve been paralyzed trying to […]

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