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EpiGenie Features call out new Methods, provide Insights into emerging trends, or sometimes just share technical tips from the experts in our community.

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Genome Synthesis vs. DNA Methylation: A Battle for One-Carbon with Dr. Patrick Stover

November 19, 2013

Dr. Patrick Stover discusses the competition between genome synthesis and DNA methylation for the use of available folate and one-carbons. The Balancing Act of Folate Metabolism So one of the primary focus of our laboratory is trying to link how changes in metabolism affect specific disease outcomes. And we’re most interested in neural tube defects […]

Methylcytosine Makes its Mark on RNA Methylation

November 6, 2013

Methylcytosine – It’s not just for DNA anymore. Despite being almost exclusively associated with DNA for decades, methylcytosine (5mC) has recently been shown to be an important base modification in RNA as well. Exploding interest in the RNA version of 5mC, what it does, and how it works, has been sparked by a sharp uptick […]

Long Distance Relationship in the Genome with Dr. Frank Grosveld

October 24, 2013

Dr. Frank Grosveld discusses distal interactions in the genome and how these might be less directed than generally thought. Long Distance Relationship in the Genome Well, I’m most excited about something that I have been working on for a long time. Which is basically how bits of the genome interact with each other. So we […]

Intergenerational Epigenetic Inheritance with Dr. Elizabeth Radford

October 22, 2013

Dr. Elizabeth Radford discusses some of the latest trends in intergenerational epigenetic inheritance. This interview was shot at the Keystone Symposia’s meeting on Nutrition, Epigenetics and Human Disease, 2013 held in Santa Fe, New Mexico Intergenerational Epigenetic Inheritance We’re collaborating with Mary-Elizabeth Patti who works at Harvard, and she has a mouse model where they undernourish […]

DNMT1-interacting RNAs (DiRs): DIY Methylation for the Locus that has Everything

October 18, 2013

The holidays are just around the corner, but the gifts are arriving early as a talented crew of epigenetics enthusiasts published some great work in Nature last week that suggests some RNA transcripts have more self control than a Jedi. Look out Luke, these under appreciated RNAs fit DNMT1 like a glove, and block local DNA methylation. […]

We are the 98%: Intergenic Regions (Finally) Get Some Buzz

October 11, 2013

Many chose to focus on the ‘wealthy’ two percent of our genome that produces protein, but we’ve always found the other 98% to be much more interesting. Thankfully, we’re past the days of referring to non-coding, intergenic regions as ‘Junk DNA’, and new research is proving how scientifically rich they really are. Dr. Emily Hodges […]

A Crash Course in Folate, Nutrition, and DNA Methylation Regulation with Dr. Patrick Stover

October 10, 2013

Dr. Patrick Stover, PhD, the Director of the Division of Nutritional Sciences at Cornell University, provides a great overview of the key role of folate in one-carbon metabolism, and DNA methylation in nutrition. Folate, Nutrition, and DNA Methylation Regulation There’s a long history in the whole field of folate metabolism, one-carbon metabolism, that outcomes […]

Inducible Models Breathe New Life into Epigenetic Inheritance Studies

October 8, 2013

Food, toxins, and stress can all have enormous effects on the epigenome, but pinning down the true epigenetic mechanisms at work is the tricky part. While it’s been difficult to determine mechanisms of action in standard animal models, new ones have been developed using Tetracyline-induced systems, that make it much simpler to tease out how […]

Is Cancer an Epigenomic Disease?

October 7, 2013

Discovering what ‘causes’ cancer has been a goal as elusive as hitting the Lottery by playing only the numbers in your birthdate. To complicate matters, most cases are unique events within themselves, adding a layer of heterogeneity that leads to even more hair-pulling frustration among researchers. However, cutting edge research has now revealed a possible […]

SNPs, Nutrition, and DNA Methylation with Dr. Steven Zeisel

October 4, 2013

Dr. Steven Zeisel discusses the intersection of genetics and epigenetics in nutrition. SNPs, Nutrition, and DNA Methylation Well, we think that there are a number of genetic variants, single nucleotide polymorphisms. I’ll call them SNPs. These SNPs are extremely common in one carbon metabolism, especially among Caucasians. And we are reporting that these SNPs […]

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