Enhancers: A Review of the “Other” Regulatory Region TimelineFebruary 10, 2014Promoters and UTRs seemed to have grabbed the better part of the limelight in recent years, but let’s not overlook enhancers. These mysterious pockets of regulatory potential are full of surprises. Read all about the epigenetic breakthroughs in the understanding of enhancers.
Epigenetics of Cancer TimelineFebruary 9, 2014Epigenetic mechanisms have been studied in cancer for decades. Unfortunately, we haven’t been around that long, but check out these great articles that capture the recent history of epigenetic breakthroughs in cancer.
The Rise of lncRNAs TimelineFebruary 9, 2014Long non-coding RNAs, also known as lncRNAs, are gaining a truck load of momentum in the field of the epigenetics. Here we highlight the hottest research, methods papers, and the occasional interview centered around these long and curvy regulatory RNAs.
Evolution of Advanced Sequencing TimelineFebruary 7, 2014In a few short years. advanced sequencing has become nearly ubiquitous. Here we provide a history of how emerging sequencing technologies have driven epigenetic research and understanding.
Zymo-Spin™ ChIP Kits Give Chromatin Immunoprecipitations the Run-aroundFebruary 5, 2014After an extensive development and beta-testing process, the innovators at Zymo Research have unveiled the new Zymo-Spin™ ChIP Kit, which provides a whole new twist to standard chromatin precipitations. Special Discount to EpiGenie Readers: Get 20% OFF and a free “Blame It On My Epigenetics” T-shirt with every purchase of Zymo-Spin™ ChIP Kit (Catalog No. […]
Three Dimensional Chromatin & DNA Replication with Dr. David GilbertFebruary 3, 2014Dr. David Gilbert discusses the ins and outs of 3-D chromosome folding, DNA replication and the highly dynamic cell nucleus. 3-D Chromatin and DNA Replication There’s no question. The thing that I’m most excited about is the uncanny alignment between three dimensional chromatin confirmation maps and replication timing. The alignment is the greatest alignment that […]
The New Players in Epigenetic Reprogramming with Dr. Wolf ReikFebruary 3, 2014Dr. Wolf Reik discusses the latest advances in epigenetic reprogramming, and what those new discoveries might lead to. The New DNA Methylation Landscape So it’s become apparent in the last two years, I guess, that there is this process of genome-wide epigenetic reprogramming which occurs naturally in germ cells, early embryo stem cells, et cetera, […]
Webinar: Mechanisms of Epigenetic Regulation in Stem Cells and DevelopmentJanuary 31, 2014Dr. Alexander Meissner discusses the roles of epigenetic mechanisms in stem cells and development. Cytosine methylation in mammals is an epigenetic modification that is largely restricted to CpG dinucleotides and serves multiple critical functions including stable repression of target promoters, maintaining genomic integrity, establishing parent-specific imprinting patterns, and silencing endogenous retrotransposon activity. In somatic tissues, […]
The Next Steps in Chromatin Contact Analysis with Dr. Gerd BlobelJanuary 20, 2014Dr. Gerd Blobel discusses emerging techniques for visualizing the interactions of RNAs and chromatin. The Future of Chromatin Contact Analysis So there are other approaches that people are taking, which is: you use FISH, for example, Fluorescent In Situ Hybridization. And this is a method that can be used to validate interactions that have been […]
Choline Metabolism, DNA Methylation, and Memory with Dr. Steven ZeiselJanuary 20, 2014Dr. Steven Zeisel discusses how maternal intake of choline effects DNA methylation during development, and can lead to better memory. This interview was shot at the Keystone Symposia’s meeting on Nutrition, Epigenetics and Human Disease, 2013 held in Santa Fe, New Mexico Choline Metabolism, DNA Methylation, and Memory So I’m more and more believing that epigenetics […]