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EpiGenie Features call out new Methods, provide Insights into emerging trends, or sometimes just share technical tips from the experts in our community.

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The Next Steps in Chromatin Contact Analysis with Dr. Gerd Blobel

January 20, 2014

Dr. Gerd Blobel discusses emerging techniques for visualizing the interactions of RNAs and chromatin. The Future of Chromatin Contact Analysis So there are other approaches that people are taking, which is: you use FISH, for example, Fluorescent In Situ Hybridization. And this is a method that can be used to validate interactions that have been […]

Choline Metabolism, DNA Methylation, and Memory with Dr. Steven Zeisel

January 20, 2014

Dr. Steven Zeisel discusses how maternal intake of choline effects DNA methylation during development, and can lead to better memory. This interview was shot at the Keystone Symposia’s meeting on Nutrition, Epigenetics and Human Disease, 2013 held in Santa Fe, New Mexico Choline Metabolism, DNA Methylation, and Memory So I’m more and more believing that epigenetics […]

DNA Methylation: The Original Anti-Virus Program

January 8, 2014

Security and anti-virus software is a must-have accessory for the internet age, but it turns out that DNA methylation has been protecting us all from retroviral infections for quite a bit longer than any computer program. A talented research team lead by Richard Meehan from the University of Edinburgh (Scotland) applied HELP-seq analysis and DNA methylation […]

Decrypting Transcription with Dr. Frank Grosveld

January 7, 2014

Dr. Frank Grosveld points out how little we actually know about the details of transcription and the molecular machinery involved. Transcription Factories We have this loop structure of the genome. And at the same time, we know that every gene that’s being transcribed, that’s active, is part of what we call transcription factories. So […]

Epigenetic Technology: 2013 Editor’s Favorites

December 18, 2013

In 2013, technology impacted nearly every facet of our lives: from improving Instagram selfies, to squeezing even more knowledge from epigenetics research. Check out some of our favorite Technology features from the past year: Genome Editing We love the potential of Genome Editing. Led by methods like CRISPR-Cas, this emerging field has really boomed this […]

Epigenetics 101: You Can’t Always Blame Your Parents with Alberto Perez

December 17, 2013

EpiGenie reader Dr. Albert Perez lays out some of the basic concepts behind epigenetics, and explains how being a red-head in Spain started him on a path to explore DNA and the epigenome.

Webinar: Covering all the Bases with Genome-Wide 5-mC and 5-hmC Sequencing

December 17, 2013

Covering all the Bases with Genome-Wide 5-mC and 5-hmC Sequencing By Dr Keith Booher, PhD. Manager of Epigenetic Services at Zymo Research Abstract: There is an ever-increasing appreciation for the remarkable ability of epigenetic modifications, such as the methylation of cytosines in DNA (5-mC), to respond to environmental cues and influence gene expression in biological […]

Promega SIRT-Glo™ Assays Illuminate the Search for Sirtuins

December 11, 2013

Sirtuins (SIRTs) sure seem to getting around. These energetic class III HDAC enzymes have their fingerprints on everything from Alzheimer’s to Inflammation, generating enough spotlight (and even a little controversy) to make even Kanye West a feel little jealous. Promega’s new SIRT-Glo™ Assays and Screening Systems are the latest tool to help researchers study the […]

Modifying Our View of Histones with Dr. Jerry Workman

December 3, 2013

Dr. Jerry Workman discusses the questions surrounding the preservation of histone marks, and the balance between histone turnover and transgenerational inheritance. The Dynamic Histone Code I think one of the most exciting things for me that’s being approached in the field more recently is how are histone marks preserved? We talk about these things carrying […]

The Loose Ends in the Chromatin-Transcription Relationship with Dr. Steven Henikoff

December 3, 2013

Dr. Henikoff discusses some of the gaps in our understanding of transcription and chromatin that still need to be filled in. The Unknowns of RNA Polymerase-Nucleosome Interactions Well, you would think with so much work done on the relationship between transcription and chromatin, the fact that there’s so many meetings on it and all. We […]

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