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Features

EpiGenie Features call out new Methods, provide Insights into emerging trends, or sometimes just share technical tips from the experts in our community.

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A “Grandiose” Project Provides a Fuzzy New Future for iPSC Research

December 17, 2014

Induced pluripotent stem cell (iPSCs) research burst on to the scene in 2006 with a paper which has since spawned thousands of studies and has proved to be a quantum leap for regenerative medicine. This reached a crescendo this year when a Japanese patient became the first recipient of retinal cells generated from iPSCs made […]

Dynamic Pseudouridylation of ncRNA and mRNA

December 15, 2014

Pseudouridine (Ψ) is not only the most abundant post-translational modification (PTM) of RNA in all organisms, but it is also amongst the first discovered, way back in the futuristic 50’s, where it was deemed the 5th nucleotide of RNA. Ψ doesn’t discriminate against cellular functions or evolutionary distinct species. And while studied intently in rRNA […]

Epigenetic Exploitation of Host Cells by Viruses

December 14, 2014

Exploitation is a common theme in all fields of biology and viruses are no exception. But now it seems that viruses are up to some creative tricks when it comes to keeping a low profile in preparation for their full attack and sneaking out a few infections, a process known as viral latency. While DNA methylation may function as […]

Reprogramming to Pluripotency: Lessons from the Egg

December 8, 2014

Have you ever wish you could just clone yourself? How much more work you’d be able to get done in a day! While creating an exact copy of yourself that knows everything you do is still very much in the realms of science fiction, cloning human cells is a reality. The first big leap came […]

New Dimensions for Pluripotent Cell Differentiation

November 23, 2014

The recent Hollywood trend of adapting much beloved movies from two-dimensional (2D) into 3-dimensional (3D) offerings hasn’t met with the expected fanfare and applause. However, strategies which have adapted pluripotent stem cell (PSC) differentiation strategies from 2D to 3D have created some masterpieces of epic proportions. Differentiating PSCs as adherent cell monolayers is a commonly […]

On the Trail of Naïve Human Pluripotent Cells

November 23, 2014

The creation of pluripotent stem-cell lines from early embryos has enabled the indefinite capture in vitro of one of nature’s most fascinating but fleeting faces. Yet, not all embryonic stem cells (ESCs) are alike. Mouse ESCs are free from differentiation bias and epigenetic restriction, whereas human ESCs have already made some fundamental developmental decisions. But […]

Two New Players for Better Differential Peak Detection in ChIP-Seq

November 22, 2014

Sometimes bioinformatics can seem a bit mystical, particularly when a tool arrives that makes you wonder what you were wasting your time doing before it. ChIP-seq is no stranger to this world and as a driver of a large proportion of epigenomic experimentation we’re also no stranger to the challenges of processing ChIP-seq data and peak calling. One of […]

Hints for Optimizing Bisulfite Primer Design

September 12, 2014

The bisulfite conversion experts from Zymo Research have put together a killer guide on the ins and outs of amplifying bisulfite treated DNA. EpiGenie got an exclusive, advanced peek at some of the content that we are sharing with our readers. In this section, they provide some helpful advice on the art of bisulfite primer […]

Get In Tune with Chromatin: Abcam High Sensitivity ChIP Kits

September 3, 2014

Today’s epigenetics researchers need to squeeze every last bit of detail from the chromatin immunoprecipitation (ChIP) experiments they run. That’s why Abcam launched their new High Sensitivity ChIP kits; to help bench scientists stay tuned in to what’s going on with the chromatin in their samples. Abcam High Sensitivity ChIP Kits sport some pretty nifty […]

EpiGenie Book Reviews: Epigenetics in Psychiatry

September 3, 2014

Weighing in at just above 600 pages, Epigenetics in Psychiatry sets out to cover emerging research interests in the world of neuroepigenomics and it’s translation to the clinic. A collection of reviews, rather than a more standard textbook, it is written by researchers in the field with a focus on the background of their research […]

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