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Features

EpiGenie Features call out new Methods, provide Insights into emerging trends, or sometimes just share technical tips from the experts in our community.

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tiRNAs Emerge from FANTOM4

July 22, 2009

As deep sequencing platforms displace Nintendo’s Wii as the most popular toy in the research community, labs are discovering new varieties of RNAs at a dizzying pace. The latest edition, transcription initiation RNAs (tiRNAs), were recently identified by scientists at the University of Queensland in Australia, and published in Nature Genetics last April, by mining […]

On Your Marks: Antibodies That Should be in Every Epigenetics Researcher’s Fridge

July 15, 2009

Chromatin is a complicated scene. Staying on top of who’s who in residue and degree-specific histone modifications and chromatin modifying proteins is more than a full time job. So, if you’re looking to jump start your investigations and pull down some quick hitting data, you’ll want to consider picking up on some quality antibodies targeting […]

This Hi-Def Methylation Experience is Brought to You by Bisulfite Capture

July 15, 2009

Even if you don’t have a new flat screen HD TV hanging in your living room, most of us have at least seen the beauty that is HD when strolling through the TV section in the local Wal-Mart or Best Buy. The picture is so crystal-clear that watching a game in HD is just like […]

miBridge: Bringing mRNA UTRs Together

July 9, 2009

When it comes to the the miRNA translational repression model, 5’ UTRs have been neglected more than California’s budget deficit in recent years. Despite computational approaches predicting oodles of miRNA docking sites for miRNAs in the 5’ UTR, we haven’t seen that many studies tackle the other side of miRNA repression. But just a few […]

Erring on the Side of Calling: Sequencing Mismatches Highlight RNA Editing

July 1, 2009

To err is enzymatic; to identify errors previously thought to be technical, but are actually biologically relevant, is divine. Most researchers view the sequencing errors from reverse transcription, sequencing reaction, or base calling part of the job. After all, with the mountains of sequence pouring off these platforms, one would expect and accept a few […]

Don’t Go Away Mad (Just GOmir)

July 1, 2009

Figuring out the targets of your favorite miRNA is no simple matter, and if it ranks somewhere between cleaning the bathroom and a trip to the dentist on your list, then you’ll want to check out a new java-based tool called GOmir which makes the miRNA target analysis experience a little less painful. A group […]

Zeroing in on miRNA Targets with HITS-CLIP

June 24, 2009

With only a modest, 6-8 nucleotide seed region required for pairing, miRNAs theoretically aren’t too fussy when it comes to which mRNAs they pair up with. But don’t let this apparent “beer goggle” regulation fool you. When it comes down to miRNA binding in vivo, miRNAs might be a little more discriminating than previously suggested. […]

miRNA qRT-PCR Data Normalization Gets Mean

June 23, 2009

Although qRT-PCR has become a popular way to profile miRNAs, it has a dirty little secret that nobody likes to talk much about; data normalization. Without convenient “housekeeping genes” to use as internal references, like you would with mRNAs, researchers have had to settle for second rate options to normalize data from miRNA experiments. A […]

Move Over MeDIP: Methyl Binding Proteins Enrich Methylation Studies

June 18, 2009

Since their debut with tiling microarrays back in 2005, DNA methylation affinity reagents have rapidly become a weapon of choice for prepping samples for genome-wide methylation studies. In the last few years enrichment methods have evolved almost as rapidly as the technology platforms on which they’re analyzed. Let’s take a look at some of the […]

Gene Bodies Take the “Hot Bod” Title for 2009

June 18, 2009

Like many other websites looking to boost their traffic, we couldn’t resist calling attention to a few hot bodies. Back in the day, Golgi Bodies were a hot research focus, and for good reason–these mini protein boot camps put the final touches on our critical cellular proteins before sending them on to their job assignments. […]

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