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EpiGenie Features call out new Methods, provide Insights into emerging trends, or sometimes just share technical tips from the experts in our community.

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Making Sense of the Grade: ChIP Validation Terminology

January 17, 2013

Antibody vendors have been hard at work to offer antibodies that are suitable for applications like ChIP. Usually these antibodies have been used successfully in peer-reviewed publications. In many cases they’ve been validated internally by an R&D team, and in some cases, each lot may be validated to work in ChIP applications. The tricky part […]

5hmC Analysis Timeline

December 10, 2012

EpiGenie has probably covered developments in 5hmC more than any topic the last couple of years, so we’ve compiled this timeline for you. Scroll along to see what you may have missed if you’ve been out of the loop or lab for a sabbatical.

EpiGenie 5hmC Technology Guide

October 31, 2012

A couple of years ago, researchers keen to analyze 5-hmC had a couple of options, but those early approaches couldn’t quite satisfy all of their increasing demands. Fast-forward a bit and it’s a very different story. Today there’s a plethora of options, each with its own strengths and weaknesses. As a result, one of the […]

Three Ways to Get Intimate with Epigenetic Marks

October 24, 2012

The days of dealing with regional estimates of epigenetic marks like histone modifications and DNA methylation are just about behind us. That’s right, the maps that lie ahead will be less Thomas Guide and more GPS. Drs. Gabriel Zentner and Steve Henikoff recently took some time off from being all-star cancer researchers and pulled together […]

Natural Antisense Transcripts within Pseudogenes

October 20, 2012

EpiGenie recently reviewed the epigenetic text Non-Coding RNAs and Epigenetic Regulation of Gene Expression by Kevin Morris. To give you a little taste of the material covered in the book, here is a summary of one of the chapters: Natural Antisense Transcripts within Pseudogenes: An EST Survey by Enrique M. Muro and Miguel A. Andrade-Navarro […]

Epigenetic Regulators (miRNAs, lncRNAs) Get Regulated Epigenetically

October 20, 2012

With Halloween coming up, perhaps it is fitting that the authors of two recent papers describe a “tangled web” of epigenetic regulations. In one paper, researchers suggest that DNA methylation and perhaps other epigenetic modifications disrupt long non-coding RNA (lncRNA) activity. In the other paper, a different team shows that DNAm messes with the miRNA […]

Webinar: Early Life Determinants of Mental Health – Epigenomic Mechanisms with Dr. Patrick McGowan

October 3, 2012

Dr. Patrick McGowan discusses the impact early-life events can have on our epigenomes in this recorded webinar. This webinar is brought to you with support from Porvair Filtration Group. Check out their line of innovative ChIP kits and reagents at chromatrap.com Abstract Human epidemiological studies and studies of animal models provide many examples by which […]

Webinar: Epigenetics of Autism – The Interface Between Genetic and Environmental Risks with Dr. Janine LaSalle

October 3, 2012

Dr. Janine LaSalle discusses some of the potential epigenetics mechanisms involved in autism spectrum disorders in this recorded webinar. This webinar is brought to you with support from Porvair Filtration Group. Check out their line of innovative ChIP kits and reagents at chromatrap.com Epigenetics of Autism Autism is an increasingly common disorder of complex etiology, […]

The State of Epigenetic Editing

September 27, 2012

If the field of epigenetics is heading into adolescence (rapid growth, disruptive, with occasional data tantrums), the arena of Epigenetic Editing (gene-specific rewriting of epigenetic marks) is more zygotic than anything, with far more questions than answers. But the concept of systematically manipulating epigenetic marks to modulate gene expression is injecting some air back into […]

RNA Methylation Adds Some Stability to a Chaotic Cell

September 26, 2012

We could all use a little more stability in our lives, and now researchers in Germany say that tRNAs get more stable when they are methylated on specific cytosines. This stability helps ensure that cells keep making proteins for proper development and differentiation. The role of cytosine-C5 methylation on tRNAs has been more mysterious than […]

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