Features

Features

EpiGenie Features call out new Methods, provide Insights into emerging trends, or sometimes just share technical tips from the experts in our community.

Search Articles

SILAC Offers a New Twist on Histone Turnover

December 15, 2010

A new technique has arrived on the scene that makes life a little easier for those of you into studying histone turnover rates. Taking advantage of technologies used by our friends in proteomics, researchers at Princeton University explored the turnover of various histone proteins and how post-translational modifications (PTMs) alter the speed of that process. […]

Enriching 5-hmC Detection with Sugar

December 15, 2010

In today’s more health conscious world, we’ve seen a surge in organic-everything. Enriching anything with sugar is a definite no-no. Good thing researchers play by their own rules. A University of Chicago research team led by Chuan He recently enriched the latest entrant to DNA methylation marks, 5-hmC, by enriching with glucose in a really […]

DNA Methylation Affinity Methods Come With Some Baggage

November 19, 2010

If you sometimes wonder about the quality of data coming from today’s popular affinity-based DNA methylation analysis methods, you‘re not alone. In fact, researchers at Garvan Institute of Medical Research in Sydney Australia decided to do something about it by studying the techniques and learning that methylated DNA immunoprecipitation (MeDIP) and methyl-CpG binding domain-based capture […]

Nucleosome Positions Are Cloudy With Chance of Stability

November 5, 2010

It’s all about perspective. Like a funhouse mirror that makes you look fat or skinny depending on how it’s curved, it seems there’s some controversy on the subject of nucleosome positioning based on how results get interpreted. So, are nucleosomes stable or do they move around? In this contributed piece, Istvan Ladunga from the University […]

That’s Sweet: Tracking Down 5-hmC with Sugar

October 26, 2010

To say researchers have been pretty amped about 5-Hydroxymethylcytosine (5-hmC) this last year would be an understatement. Is this 6th base for real, or is it some kind of intermediate of it’s more abundant cousin 5-mC? So far its low key presence has been detected in embryonic stem cells, brain, and other organs but there […]

miRNA Sponges Making a Big Splash

October 15, 2010

A few years back synthetic miRNA decoys, nicknamed “miRNA sponges”, were developed as an innovative new way to inhibit miRNA activity by bumping up the number of miRNA targets to “soak up” a specific miRNA. Now recent reports are popping up showing evidence that naturally occurring miRNA sponges have been around all along, we just […]

Grabbing Histones By The Tail

September 15, 2010

For those old-school scientists who are still using erector sets and Lincoln logs to model the interactions between histone tails and proteins, we’ve found a new interactive tool that’ll bring your histone analysis into the 21st century. A team from the Structural Genomics Consortium (a collaboration between the University of Oxford and the University of […]

Polymerase Furiosus Over Lack of Credit in Bisulfite Sequencing

September 1, 2010

At EpiGenie, we try to call attention not just to the big names in the field that nab most of the limelight, but also to the folks busting their pipettes day and night for new discoveries. So why not give a shout out to a workhorse in the most widely used method for methylation analysis, […]

The Epigenetics of Mental Illness

August 31, 2010

Mental disorders like depression will likely affect 1/6 of Americans at some point in their life. That probability might be higher if you’re a Cleveland sports fan, but seriously, with mental illnesses affecting hundreds of millions of people globally each year, we’re glad to see an increasing focus on the epigenetics of these disorders. In […]

5-Hydroxymethylcytosine Gets Sensitive

August 17, 2010

One of the great things about science is that whenever a new problem presents itself, there are always some members of the community who set out to find innovative solutions. In this case, it’s been a bear to detect and quantify 5-hydroxymethylcytosine (5-hmC) but some cagey researchers at the Ludwig Maximilians University (LMU) in Munich, […]

Pages: 1234567891011121314151617181920212223242526272829303132

TAP

Features

Featured Articles

Search Articles