In the Epitranscriptome Clusters of Co-Methylation Define m6A’s FunctionNovember 13, 2014Lately, at the EpiGenie HQ, we’ve had our mind on methylation and our money on RNA. Not just limited to DNA or Cytosine, we’ve seen that N6-methyladenosine (m6A) is a highly dynamic mark in RNA that has a critical role in stem cell differentiation. Now researchers from the Northwestern Polytechnical University in China have set out to find how m6A dynamics work on […]
Breaking Barriers: Cloning Made Easier by Erasing Epigenetic MarksNovember 5, 2014If Star Wars is anything to go by, cloning techniques of the future will be able to create a whole army of clones in the blink of an eye. Yet, back on planet Earth, the cloning of today is still relatively inefficient. A new study published in Cell identifies an important epigenetic road block in […]
in vivo CRISPR Takes Aim at Key DNA Methylation Players in the BrainOctober 31, 2014Adding to the ever growing potential of genome editing, one of the latest breakthroughs from the lab of Feng Zhang at the Broad Institute of MIT and Harvard puts CRISPR/Cas9 to the test with an interesting research trifecta of: in vivo genome editing focused on the brain genome editing that targeted DNA methylation machinery including key readers and writers. both […]
Histone Modification Reading Domains Crack Complex CombosOctober 30, 2014Having alternatives is always great, particularly when it comes to studying histone modifications. By using some recombinant proteins of histone reading domains, researchers from the lab of Albert Jeltsch at Stuttgart University (Germany) recently demonstrated that these domains might just one-up antibodies when it comes to deciphering the combos of the histone code. Lead author Goran Kungulovski shares that “Histone […]
Developmental Origin of Schizophrenia-Associated DNA MethylationOctober 30, 2014Schizophrenia is one complex disease, with a number of subtypes and an origin unknown. However, despite it’s complexity, recent evidence points toward an interaction between genes and environment that are mediated by the epigenome. Further adding to the complexity is the fact that most patients are treated with powerful antipsychotics that also remodel the epigenome in […]
