A Polymerase Evolved for Your Bisulfite Converted DNASeptember 11, 2015Bisulfite conversion can be used in so many different applications that it’s not so surprisingly referred to as the gold standard for DNA methylation analysis. But getting to the gold can create some problems for DNA. The process of converting methylated DNA (5mC) to Uracil and then finally a Thymine is harsh as it involves […]
Custom-Made Histone Modifications Add Some Bling to ChromatinSeptember 11, 2015Sure, the new Apple products announced this week represented new breakthroughs and yes, you’ll be able to personalize these devices with countless modifications like cases, color and screens. The real action though, was unfolding (pun intended) in the world of chromatin analysis as a new method surfaced for introducing tags or native modifications into histones (or any other […]
DNA Methyltransferase Teams Up with Long Non-Coding RNA to Police Colon Cancer CellsSeptember 5, 2015Mulder and Scully. Holmes and Watson. If TV and books are anything to go by, then unconventional pairings between the hot-headed detective and their calm and collected partner get results. Now it seems that another unlikely duo work together in the fight against crime of a biological nature. A new study reports that a DNA […]
ChIPmentation: The Next Fast and Low-Input ChIP-seq SensationAugust 25, 2015ChIP-Seq is the bread and butter of histone and transcription factor research. It has seen countless modifications to allow it to perform under all the variables biology can throw at it, but with that specialization has come limitations to generalization. Now the methodological maestros in the lab of Christoph Bock, which brought us single-cell methylome sequencing, […]
Epigenetics Drives Genetics Straight Into EvolutionAugust 9, 2015In today’s fast-paced world, quickly adapting to your environment is a game-changer. But genetic determinism cannot fully explain the rapid adaption seen in many species, which has left evolution in a dark age. That is until the enlightening work of Michael Skinner’s laboratory at Washington State University. Their observations on transgenerational epigenetic inheritance have been […]
