Smooth as Silc1: A ncRNA Lnc to Nerve RegenerationNovember 6, 2018When it comes to nerve damage, the mammalian peripheral nervous system (PNS) is arms and legs ahead of the central nervous system (CNS) in its ability to regenerate damaged neurons. While neuroscientists already knew that the PNS has an innate ability to express pro-regenerative transcription factors after injury, a new paper has the nerve to […]
Histonagram: C. elegans Sperm Carry a Histone Memory of Spermatogenesis and OogenesisOctober 31, 2018While Instagram may have replaced the Polaroid, some age-old memories just can’t be shaken. Thankfully, the sperm epigenome of C. elegans has conjured up the latest social media trend, the histonagram: a histone based memory of spermatogenesis and oogenesis that shapes offspring fertility. Although C. elegans differ from us humans in that they don’t make use […]
Paradigm Shift for Intergenerational Epigenetic Effects at Retrotransposons: The Exception Rather than the Rule?October 30, 2018While friendly customer service and helpful views in article comments sections may once have been ubiquitous occurrences, they now, unfortunately, seem to be the exception rather than the rule. This trend extends to some of our favorite epigenetic topics, where a team led by Anne C. Ferguson-Smith (University of Cambridge, United Kingdom) now provides paradigm-breaking […]
H3K27ac Histone Acetylome-Wide Association Study Enhances our Knowledge of Alzheimer’s Disease BrainOctober 30, 2018When it comes to the complex disorders associated with aging, our knowledge could always use some enhancement. Thankfully, a new histone acetylome-wide association study (HAWAS) of H3K27ac establishes that this mark of active enhancers can also enhance our knowledge of Alzheimer’s disease (AD). The role of histone acetylation in healthy aging and AD has begun […]
A Microbiome-Sensitive H3K4me3 Profile Predicts Intestinal Inflammation in Crohn’s DiseaseOctober 30, 2018While our microbiome serves up the metabolites required for our histone modifications, new findings establish that this agglomeration of microorganisms can also serve up a dish most foul; one that induces a severe type of inflammatory bowel disease (IBD) known as Crohn’s disease. Although studies have established a link between alterations to the microbiome and […]
