MeRIP-seq, N1-methyladenosine (m1A), and the Expanding EpitranscriptomeFebruary 23, 2016There’s no denying that understanding a new language can be tricky. Without a complete alphabet, the most important messages can be lost in translation. When it comes to complex languages, the epigenome is no exception. There are a number of RNA base modifications involved in post transcriptional regulation, including pseudouridine (Ψ) and 5hmC, and there’s […]
Towards Blood DNA Methylation as a Pan-Cancer Surveillance ScreenFebruary 5, 2016Early and less tedious cancer diagnosis can prevent future complications and improve patient outcome, however past studies have revealed that the markers of most cancers are as unique as snowflakes. An enticing solution for this heterogeneity would be to screen for any type of cancer using one detection system to ‘rule them all’. Differential DNA […]
DNA Methylation and Transcription Data from Single Stem CellsJanuary 28, 2016Ever wanted to be able to do two things at the same time? Like work and have a social life? Eat pizza and still fit in your new purchases? Pat your head and rub your belly? While these highly important combinations remain almost impossible (at least for the EpiGenie staff), a stellar cast of scientists […]
RNA Hydroxymethylcytosine Targets the MessengerJanuary 28, 2016A new paper adds another RNA modification to the list already published, but with exciting news for the epigenetics enthusiasts out there… the characterized modification is RNA 5-hydroxymethylcytosine (5hmrC), an important mark previously discovered on DNA. The laboratory of François Fuks at ULB in Brussels decided to look deeper into the presence of 5hmC on […]
Viva in vivo Gene Editing: A Roundup of the Latest CRISPR HitsJanuary 28, 2016Gene editing with CRISPR/Cas9 is here, there, and everywhere. We have seen gene editing in human somatic cells, pluripotent stem cells, and even embryos. However, we should also be looking at CRISPR-based gene editing somewhere else: in a living, breathing human. The question is – where does the current technology stand on the in vivo […]
