mRNA Shows Its Age and Quiets Down the Immune System with Cap2 MethylationFebruary 14, 2023Wrinkles, gray hair, … Cap2 methylation on mRNA? It turns out that these are all signs of aging. Two elegant new methods to show that Cap1 gets slowly modified to Cap2 as mRNAs age. And just like boomers, they want to live the quiet life, calming down the innate immune system to prevent autoimmunity. Although […]
You Aren’t Going Crazy – Losing It at the Epigenetic Level Really Drives Aging!February 6, 2023Information loss can drive us crazy – from ruining a potential culinary masterpiece to turning a Lego-building afternoon into a nightmare, but can “losing it” at the epigenetic level drive aging and turn a young whippersnapper into an old fogey? We know all too well about age-related epigenetic changes, and now a team led by […]
Taking “CoRSIV” Writing from Short Notes to “Novel” Epigenetic Findings in Disease RiskJanuary 30, 2023Previously, a perfectly-penned study uncovered a type of DNA methylation variation “written” in the genome, which varies from person to person but remains consistent across tissues. Deciphering these “CoRSIV” (correlated regions of systemic interindividual variation) notes supported a deeper understanding of epigenetic variance and the impact on disease, with blood DNA methylation profiles from these […]
Active DNA Demethylation as a Source of DNA Damage at EnhancersJanuary 3, 2023Paint a self-portrait, build a house? If, instead, your more achievable New Year’s resolution was to be more active, new and exciting findings on how the abundance of single-strand DNA breaks (SSBs) at neuronal enhancers represents an intermediate of active DNA demethylation will be right down your alley! Researchers led by Wei Wu and André […]
eBook: Epigenetics & DNA MethylationNovember 21, 2022One of the longest-known and most studied epigenetic markers is DNA methylation, which can regulate gene expression and genomic organization in nearly all organisms. In eukaryotes, the primary modification of DNA is found in cytosines (C), where DNA Methyltransferases mediate the transfer of a methyl group to cytosines, converting them to 5-methylcytosine (5-mC), minor modifications […]
