Active DNA Demethylation as a Source of DNA Damage at EnhancersJanuary 3, 2023Paint a self-portrait, build a house? If, instead, your more achievable New Year’s resolution was to be more active, new and exciting findings on how the abundance of single-strand DNA breaks (SSBs) at neuronal enhancers represents an intermediate of active DNA demethylation will be right down your alley! Researchers led by Wei Wu and André […]
eBook: Epigenetics & DNA MethylationNovember 21, 2022One of the longest-known and most studied epigenetic markers is DNA methylation, which can regulate gene expression and genomic organization in nearly all organisms. In eukaryotes, the primary modification of DNA is found in cytosines (C), where DNA Methyltransferases mediate the transfer of a methyl group to cytosines, converting them to 5-methylcytosine (5-mC), minor modifications […]
Placental Proxies: A Shared DNA Methylation Profile Between cffDNA and BrainSeptember 27, 2022When you’re looking to access the latest and greatest publications, your VPN is the proxy you need. But now, there’s a new proxy in town to help with your quest for neurodevelopmental epigenetic information: Placenta and the cell free fetal DNA (cffDNA) that originates from it. A dynamic duo of papers from the lab of Janine LaSalle (UC Davis […]
RNA Methylation and DNA Demethylation Teamwork Make the Transcriptional Dream WorkSeptember 25, 2022Dream teams come in all shapes and sizes, from the 1970 Brazil football team to the Mercedes F1 team of the 2010s. A new epigenetic alliance formed between RNA methylation and DNA demethylation recently made its competitive debut and now shows how teamwork makes the dream work! A synergistic team led by Dongxin Lin, Jian […]
eBook: Epigenetics of COVID-19September 22, 2022COVID-19 has been one of the biggest public health issues in recent history and has changed the daily lives of almost everyone on the planet. Many researchers, biotechnology and pharmaceutical companies have been working around the clock since the novel coronavirus outbreak started to try to develop new tools to test for and treat the […]