BrdU Kicks Out DNA Methylation and Kicks Off Stem Cell DifferentiationMarch 7, 2012For many things in life, convenience comes at a cost. Like living in a great city with everything at your doorstep, but the rents are sky-high. A new report says that the use of BrdU, a popular tool for detecting replicating cells (such as neural stem cells in the brain), also comes with a cost, […]
3.7M CpGs Await with Improved Methyl-Seq Target EnrichmentMarch 3, 2012March 3, 2012 Instead of sequencing (and paying for, managing, storing, and analyzing) everything, target enrichment blazes through samples like a combine, harvesting for regions of interest. Even as sequencing costs drop towards that “$1,000 genome” level, enriching for select targets makes a lot of sense, especially if you only want to look at a […]
Epigenetics at the Intersection of Environment and SelectionFebruary 28, 2012One of the most fascinating things about epigenetics is the implication it has for inheritance and evolution. Theories and hypotheses are everywhere, of course, but until Sir Richard Branson launches a Virgin Time Travel business, actually measuring the changes from thousands of years of natural selection will remain a pretty tall order. Two recent papers […]
The New Human Epigenome Browser from WashUFebruary 23, 2012Looking for the latest in epigenome data analysis tools? Then you’ll want to check out Washington University’s latest creation; The Human Epigenome Browser. Built as part of the Roadmap Epigenomics Project to house and view Human Epigenome Atlas data, this new platform comes with all sorts of slick features to make analyzing, comparing and integrating […]
Emerging Details On Monoallelic Silencing in TumorsFebruary 19, 2012It’s funny how research can pay off in surprising ways. In this case, University of Wisconsin scientists were studying the tumor suppressor gene APC when they realized there was an unusual brand of monoallelic silencing going on. Earlier studies have found that many early adenomas begin with the loss of function of the Adenomatous polyposis […]
