Single Tube DNAm Analysis. Better Than Sliced Bread?April 6, 2010Tired of performing DNA extractions, bisulfite conversions, and PCR in three separate reactions? Is the sweet smell of phenol not helping you out with the opposite sex? Then, you’ll love DNA methylation analysis using methylation on beads (MOB)! Although it may sound like the stuff of infomercials, a team at Johns Hopkins University really found […]
The Secret Life of 5-AzacytidineMarch 29, 20105-azacytidine has been in the public eye for quite a while now, and it’s been widely known as a powerful demethylating agent in clinical trials for cancer. So you can imagine our surprise when a new publication in Epigenetics caught 5-azacytidine also living a secret life of reorganizing histone modifications…lots of them. Researchers from UC […]
EpiGenie Gets a Face LiftMarch 18, 2010Since we launched EpiGenie two years ago, we’ve been redesigning it and putting various bandages on it to share information a little better. Well, three web developers and a bunch of late nights later, we’re psyched to present our new look and feel. What’s New? We made a number of changes to design and our […]
The Aging Methylome and CancerMarch 15, 2010Between the body aches and wrinkles, most of us don’t need to be reminded that getting old is the most significant health risk. A new report in Genome Research explains how promoters of certain Polycomb group protein target genes (PCGTs) become increasingly hypermethylated as we age; leaving us more at risk for cancer. The link […]
SCAN-ing For Chromatin GoldMarch 2, 2010If you run enough tedious ChIP experiments, it feels like you might as well be panning for gold back in the 1800s; doing a lot of work for a few nuggets of data. Luckily some technological wizards at Cornell University have your back and are working on a new system called SCAN (Single Chromatin Analysis […]