MeRIP-seq, N1-methyladenosine (m1A), and the Expanding EpitranscriptomeFebruary 23, 2016There’s no denying that understanding a new language can be tricky. Without a complete alphabet, the most important messages can be lost in translation. When it comes to complex languages, the epigenome is no exception. There are a number of RNA base modifications involved in post transcriptional regulation, including pseudouridine (Ψ) and 5hmC, and there’s […]
Towards Blood DNA Methylation as a Pan-Cancer Surveillance ScreenFebruary 5, 2016Early and less tedious cancer diagnosis can prevent future complications and improve patient outcome, however past studies have revealed that the markers of most cancers are as unique as snowflakes. An enticing solution for this heterogeneity would be to screen for any type of cancer using one detection system to ‘rule them all’. Differential DNA […]
DNA Methylation and Transcription Data from Single Stem CellsJanuary 28, 2016Ever wanted to be able to do two things at the same time? Like work and have a social life? Eat pizza and still fit in your new purchases? Pat your head and rub your belly? While these highly important combinations remain almost impossible (at least for the EpiGenie staff), a stellar cast of scientists […]
Stress Accelerates Epigenetic AgeingDecember 18, 2015The epigenetic clock has developed faster than the iWatch: it can predict biological age from select CpGs, which when compared with chronological age, gives a metric known as Δ-age. The greater the difference, the greater the acceleration of epigenetic age, which indicates variation in the rate of senescence between people. To understand this variation and […]
Epigenetic Diversity Teams Up with Genetics to Explain Complex PhenotypesDecember 4, 2015If epigenetics has taught us anything, it’s that genes are not our destiny. Even though aberrant patterns of epigenetic marks have been caught at the scene of the crime in many disease states, we know relatively little about their natural variation and how this influences human health. That may be about to change however with […]
